Results 1 to 10 of about 37 (36)

Prostaglandins F2α and E2 in rat placenta and fetal membrane: a comprehensive immunohistochemistry of their synthetic enzymes and in vivo tissue levels during normal pregnancy.

The Journal of veterinary medical science, 2021
We determined a comprehensive immunohistochemistry of putative isoforms of enzymes for prostaglandin (PG) F2α and PGE2 biosynthesis and these PGs levels in placenta and fetal membrane of normal pregnant rats in vivo. Placenta and fetal membrane showed positive immunoreactions for phospholipase A2 group 4A, but not group 2A, and cyclooxygenase (COX)-1 ...
SATOH, Hironori, TERASHIMA, Ryota, KAWAMINAMI, Mitsumori, KURUSU, Shiro   +3 more
openaire   +4 more sources

Inflamm-aging and arachadonic acid metabolite differences with stage of tendon disease. [PDF]

PLoS ONE, 2012
The contribution of inflammation to the pathogenesis of tendinopathy and high prevalence of re-injury is not well established, although recent evidence suggests involvement of prostaglandins.
Stephanie Georgina Dakin, Jayesh Dudhia, Natalie Jayne Werling, Dirk Werling, Dilkush Robert Ephrem Abayasekara, Roger Kenneth Whealands Smith   +5 more
doaj   +1 more source

Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease. [PDF]

PLoS ONE, 2011
Chagas disease, caused by infection with Trypanosoma cruzi, is an important cause of cardiovascular disease. It is increasingly clear that parasite-derived prostaglandins potently modulate host response and disease progression.
Shankar Mukherjee, Fabiana S Machado, Huang Huang, Helieh S Oz, Linda A Jelicks, Cibele M Prado, Wade Koba, Eugene J Fine, Dazhi Zhao, Stephen M Factor, J Elias Collado, Louis M Weiss, Herbert B Tanowitz, Anthony W Ashton   +13 more
doaj   +1 more source

EFFECT OF VERAPAMIL ON THE PULMONARY VASOCONSTRICTOR ACTION OF PROSTAGLANDIN F_2α AND A SYNTHETIC PGH₂ ANALOGUE [PDF]

British Journal of Pharmacology, 1981
The vasopressor response to prostaglandin F2α (PGF2α) and to ((15S)‐hydroxy‐11α, 9α‐(epoxymethano)‐prosta‐5Z, 13E‐dienoic acid) (U‐46619) in the canine isolated lung lobe was significantly attenuated following the administration of verapamil. The pressor response to arachidonic acid (AA) was not affected by the presence of verapamil.
A D, Angerio, T M, Fitzpatrick, P A, Kot, P W, Ramwell, J C, Rose   +4 more
openaire   +2 more sources

Luteal function and oestrus in gilts treated with a synthetic analogue of prostaglandin F-2α (ICI 79,939) at various times during the oestrous cycle [PDF]

Reproduction, 1976
Treatment of cattle with various doses of prostaglandin (PG) F-2α by subcutaneous injection (Lauderdale, 1972) or by nonsurgical intrauterine injection (Rowson, Tervit & Brand, 1972; Liehr, Marion & Olson, 1972; Louis, Hafs & Morrow, 1972) induces luteal regression and allows oestrus to occur if initiated after Days 3 or 4 of the oestrous ...
H D, Guthrie, C, Polge
openaire   +2 more sources

Avaliação econômica das associações fixas de prostaglandina/prostamida e timolol no tratamento do glaucoma e da hipertensão ocular Economic evaluation of Prostaglandin/Prostamide and timolol fixed combinations in the treatment of glaucoma and ocular hypertension

Revista Brasileira de Oftalmologia, 2010
OBJETIVO: Avaliar o custo ao final de 5 anos, a efetividade e a relação custo-efetividade das associações fixas de prostaglandina ou prostamida com timolol 0,5% para o tratamento do glaucoma e da hipertensão ocular no Estado de Minas Gerais, Brasil ...
Ricardo Augusto Paletta Guedes, Vanessa Maria Paletta Guedes, Julia Linhares Borges, Alfredo Chaoubah   +3 more
doaj   +1 more source

Synchronization of estrus and ovulation with in-tramuscular injection of prostaglandin F<SUB>2α</SUB> followed by additional synthetic LH-releasing hormone in the cow

The Japanese journal of animal reproduction, 1978
Yoshihiro KANEDA, Ikuo DOMEKI, Hideo KAMOMAE, Tatsuo NAKAHARA   +3 more
openaire   +2 more sources

Synthetic Modification of Prostaglandin F2α Indicates Different Structural Determinants for Binding to the Prostaglandin F Receptor Versus the Prostaglandin Transporter

Molecular Pharmacology, 2000
Several principles governing the binding of E series prostaglandins to EP receptors have emerged in recent years. The C-1 carboxyl group binds electrostatically to a conserved arginine residue in the seventh transmembrane segment of the receptor. Prostaglandin E analogs involving bioisosteric replacements of the carboxyl group, such as acylsulfonamide,
V L, Schuster, S, Itoh, S W, Andrews, R M, Burk, J, Chen, K M, Kedzie, D W, Gil, D F, Woodward   +7 more
openaire   +2 more sources

THE TERMINATION OF PREGNANCY BY INTRAVENOUS INFUSION OF A SYNTHETIC PROSTAGLANDIN F_2α ANALOGUE

BJOG: An International Journal of Obstetrics & Gynaecology, 1973
SummaryA synthetic analogue of prostaglandin F2α was successfully used to induce abortion in six patients, five of whom were in the second trimester of pregnancy. Five of the patients had a complete abortion and in one the abortion was incomplete. The mean induction‐abortion interval was 25 hours 15 minutes, ranging from 7 hours 45 minutes to 49 hours ...
D S, Sharp, R W, Burslem
openaire   +2 more sources

Therapeutic uses of prostaglandin F2α analogues in ocular disease and novel synthetic strategies

Prostaglandins & Other Lipid Mediators, 2013
The pharmacological management of glaucoma and ocular hypertension has significantly changed over the last 18 years with the introduction of PGF2α analogues, more specifically latanoprost (6), travoprost (8), bimatoprost (10) and tafluprost (12). Prostanoids are currently the first-line medicines among ocular antihypertensive drugs in terms of efficacy,
Iwona, Dams, Jaromir, Wasyluk, Marek, Prost, Andrzej, Kutner   +3 more
openaire   +2 more sources