Results 21 to 30 of about 131,150 (281)

Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]

, 2009
The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA   +2 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography [PDF]

, 2017
By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ(9)-THC in medicinal marijuana (Bedrocan®).
Cavazzini, A, D'Acquarica, I, Gasparrini, F., Ismail, O, Manzo, C, Mazzoccanti, G, Villani, C, Wilcox, M   +7 more
core   +2 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Atrial natriuretic factor [PDF]

, 1987
The discovery of the first well-defined natriuretic hormone, the Atrial Natriuretic Factor (ANF), has prompted research on its impact on volume regulation in health and disease.
A.L. Gerbes, Ames, Anderson, Anderson, Arendt, Arendt, Arendt, Arendt, Atlas, Ballermann, Ballermann, Barakat, Bichet, Bichet, Biollaz, Bompiani, Bonkovsky, Bourgoignie, Brabant, Bricker, Buckalew, Burghardt, Burnett, Campbell, Chartier, Conn, Cuneo, Currie, De Wardener, DeBold, DeBold, DeWardener, Epstein, Epstein, Epstein, Epstein, Epstein, Fernandez-Cruz, Forssmann, Fyhrquist, G. Paumgartner, Ganger, Gauer, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerzer, Gerzer, Ginés, Goodfriend, Hartshorne, Henry, Jimenez, Jüppner, Kisch, Kramer, Laffi, Lang, Laragh, Maack, Manning, Marin-Grez, Morgan, Naruse, Needleman, Needleman, Nishiuchi, Nozuki, Ogihara, R.M. Arendt, Renner, Richards, Richards, Richards, Riegger, Ring-Larsen, Rosoff, Sagnella, Sagnella, Salerno, Samson, Schafferhans, Shenker, Sherlock, Shimizu, Thibault, Tikkanen, Uehlinger, Valdivieso, Wambach, Weidmann, Wernze, Wilkinson, Wong, Yamaji, Zipser   +99 more
core   +1 more source

pH-Triggered Assembly of Endomembrane Multicompartments in Synthetic Cells

ACS Synthetic Biology, 2021
By using electrostatic interactions as driving force to assemble vesicles, the droplet-stabilized method was recently applied to reconstitute and encapsulate proteins, or compartments, inside giant unilamellar vesicles (GUVs) to act as minimal synthetic ...
F. Lussier, M. Schröter, Nicolas J. Diercks, Kevin Jahnke, Cornelia Weber, C. Frey, I. Platzman, Joachim P. Spatz   +7 more
semanticscholar   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults with Inflammatory Bowel Disease: Data from a Large Administrative Claims Cohort

Arthritis Care &Research, Accepted Article.
Objectives The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in this population, but safety data are mixed. Methods This retrospective cohort study included patients with IBD ≥ 18 years of age from Optum's de‐identified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

Dietary Intake of Natural Sources of Docosahexaenoic Acid and Folate in Pregnant Women of Three European Cohorts [PDF]

, 2008
Background: Folic acid plays a fundamental role in cell division and differentiation. Docosahexaenoic acid (DHA) has been associated with infantile neurological and cognitive development.
Campoy, C., Decsi, Tamás, Dolz, V., Franke, Corinna, Koletzko, Berthold, Trak-Fellermeier, M., Verwied-Jorky, Sabine   +6 more
core   +1 more source

Synthetic Glycobiology: Parts, Systems, and Applications

ACS Synthetic Biology, 2020
Protein glycosylation, the attachment of sugars to amino acid side chains, can endow proteins with a wide variety of properties of great interest to the engineering biology community. However, natural glycosylation systems are limited in the diversity of
Weston K. Kightlinger, Katherine F. Warfel, M. DeLisa, M. Jewett   +3 more
semanticscholar   +1 more source