Prostanoid Signaling in Cancers: Expression and Regulation Patterns of Enzymes and Receptors
Biology, 2022 Cancer-associated disturbance of prostanoid signaling provides an aberrant accumulation of prostanoids. This signaling consists of 19 target genes, encoding metabolic enzymes and G-protein-coupled receptors, and prostanoids (prostacyclin, thromboxane ...
Pavel V. Ershov +4 more
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Trypanosoma cruzi infection and endothelin-1 cooperatively activate pathogenic inflammatory pathways in cardiomyocytes. [PDF]
PLoS Neglected Tropical Diseases, 2013 Trypanosoma cruzi, the causative agent of Chagas' disease, induces multiple responses in the heart, a critical organ of infection and pathology in the host.
Ricardo S Corral +4 more
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Modeling of biological doses and mechanical effects on bone transduction [PDF]
Journal of Theoretical Biology 274, 1 (2011) 36-42, 2011 Shear stress, hormones like parathyroid and mineral elements like calcium mediate the amplitude of stimulus signal which affects the rate of bone remodeling. The current study investigates the theoretical effects of different metabolic doses in stimulus signal level on bone.
arxiv +1 more source
Aldo-keto reductases 1B in adrenal cortex physiology
Frontiers in Endocrinology, 2016 Aldose reductase proteins are cytosolic monomeric enzymes, belonging to the aldo-keto reductase (AKR) superfamily. They perform oxidoreduction of carbonyl groups from a wide variety of substrates such as aliphatic and aromatic aldehydes or ketones.
Emilie PASTEL +3 more
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Heliyon, 2023 Background: Most labor-related problems can be attributed to the uterine myometrium muscle, as this irritable tissue must suppress its irritability potential during pregnancy.
Farideh Zafari Zangeneh +1 more
doaj
Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions. [PDF]
PLoS ONE, 2009 Prostaglandin F(2alpha) (PGF(2alpha)), represses ovarian steroidogenesis and initiates parturition in mammals but its impact on adrenal gland is unknown.
Sarah Lambert-Langlais +13 more
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Molecules, 2018 Cyclooxygenase 2 (COX-2) is an inducible enzyme responsible for the conversion of arachidonic acid into the prostaglandins, PGG2 and PGH2. Expression of this enzyme increases in inflammation.
Michelle Y. Cortes-Salva +8 more
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Ixodes ricinus tick lipocalins: identification, cloning, phylogenetic analysis and biochemical characterization. [PDF]
PLoS ONE, 2008 BACKGROUND: During their blood meal, ticks secrete a wide variety of proteins that interfere with their host's defense mechanisms. Among these proteins, lipocalins play a major role in the modulation of the inflammatory response.
Jérôme Beaufays +9 more
doaj +1 more source
Effects of arachidonic acid supplementation in maturation diet on female reproductive performance and larval quality of giant river prawn (Macrobrachium rosenbergii) [PDF]
PeerJ, 2016 The giant river prawn (Macrobrachium rosenbergii) is one of the most farmed freshwater crustaceans in the world. Its global production has been stalling in the past decade due to the inconsistent quality of broodstock and hatchery-produced seeds.
Chanpim Kangpanich +3 more
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Increased cyclooxygenase-2-derived prostanoids contributes to the hyperreactivity to noradrenaline in mesenteric resistance arteries from offspring of diabetic rats. [PDF]
PLoS ONE, 2012 This study analyzed the effect of in utero exposure to maternal diabetes on contraction to noradrenaline in mesenteric resistance arteries (MRA) from adult offspring, focusing on the role of cyclooxygenase (COX)-derived prostanoids.
Fernanda E Ramos-Alves +5 more
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