Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue [PDF]
, 2020 Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases.
Dittmar, Gunnar +10 more
core +1 more source
Enzymic separatory determination of prostaglandin F and F.
Chemical and Pharmaceutical Bulletin, 1975 A simple and sensitive method is described for separatory determination of prostaglandin E and prostaglandin F. This method is based on three principles : (1) Prostaglandin E and prostaglandin F are oxidized by prostaglandin dehydrogenase, resulting reduced nicotinamide-adenine dinucleotide (NADH).
T, Itami +3 more
openaire +3 more sources
Prostanoid Signaling in Cancers: Expression and Regulation Patterns of Enzymes and Receptors
Biology, 2022 Cancer-associated disturbance of prostanoid signaling provides an aberrant accumulation of prostanoids. This signaling consists of 19 target genes, encoding metabolic enzymes and G-protein-coupled receptors, and prostanoids (prostacyclin, thromboxane ...
Pavel V. Ershov +4 more
doaj +1 more source
Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. [PDF]
, 2016 The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood.
Currais, Antonio +5 more
core +2 more sources
Trypanosoma cruzi infection and endothelin-1 cooperatively activate pathogenic inflammatory pathways in cardiomyocytes. [PDF]
PLoS Neglected Tropical Diseases, 2013 Trypanosoma cruzi, the causative agent of Chagas' disease, induces multiple responses in the heart, a critical organ of infection and pathology in the host.
Ricardo S Corral +4 more
doaj +1 more source
Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells [PDF]
, 1987 The influence of the fungoid undecapeptide cyclosporin A (CyA) on PGE2 release from cultured rat aortic smooth muscle cells was investigated in this study.
Koch, K. M. +3 more
core +1 more source
Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: nutritional implications for cardiometabolic diseases [PDF]
, 2020 Prospective observational studies support the use of long-chain omega-3 polyunsaturated fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; however, randomised controlled trials, have often reported neutral findings ...
Abdelhamid +136 more
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Molecules, 2018 Cyclooxygenase 2 (COX-2) is an inducible enzyme responsible for the conversion of arachidonic acid into the prostaglandins, PGG2 and PGH2. Expression of this enzyme increases in inflammation.
Michelle Y. Cortes-Salva +8 more
doaj +1 more source
Changes in PGE2 signaling after submandibulectomy alter post–tooth extraction socket healing [PDF]
, 2018 Saliva is very important to oral health, and a salivary deficit has been shown to bring serious problems to oral health. There is scant information about the mechanisms through which salivary glands participate in post–tooth extraction socket healing ...
Bozzini, Clarisa +5 more
core +1 more source
5-HT2A receptor enhancement of contractile activity of the porcine urothelium and lamina propria [PDF]
, 2016 OBJECTIVES: To examine the effect of 5-hydroxytryptamine (5-HT; serotonin) on the contractile properties of the urothelium and lamina propria, as a better understanding of bladder physiology might aid the development of new treatments.METHODS: Strips of ...
Alexander +29 more
core +1 more source