Results 251 to 260 of about 50,411 (300)
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Molecular Pharmacology, 2000
Several principles governing the binding of E series prostaglandins to EP receptors have emerged in recent years. The C-1 carboxyl group binds electrostatically to a conserved arginine residue in the seventh transmembrane segment of the receptor. Prostaglandin E analogs involving bioisosteric replacements of the carboxyl group, such as acylsulfonamide,
V L, Schuster +7 more
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Several principles governing the binding of E series prostaglandins to EP receptors have emerged in recent years. The C-1 carboxyl group binds electrostatically to a conserved arginine residue in the seventh transmembrane segment of the receptor. Prostaglandin E analogs involving bioisosteric replacements of the carboxyl group, such as acylsulfonamide,
V L, Schuster +7 more
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ChemInform Abstract: STEREOSELECTIVE REDUCTION OF PROSTAGLANDINS E TO PROSTAGLANDINS F
Chemischer Informationsdienst, 1980AbstractDie Prostaglandine E (I) gehen bei der Reduktion mit Li in Tetrahydrofuran und flüssigem Ammoniak in die Prostaglandine Fß(II) über.
V. I. MEL'NIKOVA, K. K. PIVNITSKII
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Roles of Prostaglandin F Synthase
2001Prostaglandin (PG) F2 is widely distributed in various organs, and exhibits various biological actions such as smooth muscle contraction of uterus [1], bronchus [2], and trachea [3], the initiation of parturition [4], and pain transmission [5]. PGF synthase (PGFS) is a dual function enzyme, which catalyzes the reduction of not only PGD2 but also PGH2 ...
Kikuko Watanabe +5 more
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Conformations of Prostaglandin F 2α and Recognition of Prostaglandins by Their Receptors
Science, 1977The conformation of prostaglandin F 2α (PGF 2α ) has been determined by x-ray diffraction techniques. Two independent conformers of PGF 2α , studied as the tris(hydroxymethyl)methylamine salt, are observed to adopt the familiar "hairpin" conformation with the α and ω ...
D A, Langs, M, Erman, G T, DeTitta
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Journal of the American Chemical Society, 1971
This is an explanation of 2 highly specific reductive processes for the interconversion of primary PGs (prostaglandins). The laboratory procedures are described in detail and the chemical structures of substances involved in the process are diagrammed. A stereospecific reduction of PGE to PGFalpha is described.
E J, Corey, R K, Varma
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This is an explanation of 2 highly specific reductive processes for the interconversion of primary PGs (prostaglandins). The laboratory procedures are described in detail and the chemical structures of substances involved in the process are diagrammed. A stereospecific reduction of PGE to PGFalpha is described.
E J, Corey, R K, Varma
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Plasma prostaglandin F metabolite concentrations following cervical encerclage
Prostaglandins, 1980Peripheral plasma concentrations of 13, 14-dihydro-15-keto prostaglandin F2 alpha (PGFM) were measured in seven women having elective cervical encerclage in an otherwise normal pregnancy. Three of seven patients had a statistically significant elevation of PGFM levels at 60 minutes after commencement of surgery.
P S, Cocks +4 more
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Possible role of prostaglandin F in blastocyst implantation
Prostaglandins, 1986The synthesis and release of Prostaglandin F (PGF) by the rabbit blastocyst and endometrium were investigated on Day 6 and Day 7, using radioimmunoassay, autoradiography and conversion experiments. The following results were obtained: The content of PGF in the blastocyst increased significantly (P less than 0.01) from Day 6 to Day 7. The content of PGF
M, Kasamo +4 more
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Colostomy irrigation with prostaglandin F2α
Diseases of the Colon & Rectum, 1982Prostaglandin F2α applied directly in quantities up to 400 μ g had no clinical effect on the emptying time of the colon in patients undergoing colostomy irrigation.
U, Christensen, J, Kjaergaard, F, Stadil
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Asia-Oceania Journal of Obstetrics and Gynaecology, 1984
AbstractConcentrations of prostaglandin F and steroids in plasma and in corpus luteum (CL) were studied by radioimmunoassay during the luteal phase of the menstrual cycle in thirteen normal women.The average concentration of PGF in corpus luteum was 4.19 ± 1.59 ng/g (mean ± SE) (ranging from 0.03 to 20.5 ng/g) and in plasma was 208.1 ± 34.7 pg/ml ...
Shoichi Tanaka +5 more
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AbstractConcentrations of prostaglandin F and steroids in plasma and in corpus luteum (CL) were studied by radioimmunoassay during the luteal phase of the menstrual cycle in thirteen normal women.The average concentration of PGF in corpus luteum was 4.19 ± 1.59 ng/g (mean ± SE) (ranging from 0.03 to 20.5 ng/g) and in plasma was 208.1 ± 34.7 pg/ml ...
Shoichi Tanaka +5 more
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Prostaglandins, 1978
Abstract The relationship between progesterone (P 4 ) synthesis in vitro by luteal tissue and prostaglandin F (PGF) synthesis in vitro by endometrium and luteal tissue from two stages of the cycle, Days 7 to 8 and 15 to 16, was determined.
H D, Guthrie, C E, Rexroad, D J, Bolt
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Abstract The relationship between progesterone (P 4 ) synthesis in vitro by luteal tissue and prostaglandin F (PGF) synthesis in vitro by endometrium and luteal tissue from two stages of the cycle, Days 7 to 8 and 15 to 16, was determined.
H D, Guthrie, C E, Rexroad, D J, Bolt
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