Results 31 to 40 of about 226,677 (159)

Female Type 1 Diabetic Akita Mice Demonstrate Increased Bladder Contractility via FP Receptor Activation due to NLRP3-Mediated Inflammation

Frontiers in Bioscience-Landmark
Background: Diabetic bladder dysfunction (DBD) is driven in part by inflammation which dysregulates prostaglandin release in the bladder. Precise inflammatory mechanisms responsible for such dysregulation have been elusive.
Michael R. Odom, Francis M. Hughes Jr., NiQuava Pope, Huixia Jin, J. Todd Purves   +4 more
doaj   +1 more source

Multiplicative functions commutable with binary quadratic forms $x^2 \pm xy + y^2$ [PDF]

arXiv, 2022
If a multiplicative function $f$ is commutable with a quadratic form $x^2+xy+y^2$, i.e., \[ f(x^2+xy+y^2) = f(x)^2 + f(x)\,f(y) + f(y)^2, \] then $f$ is the identity function. In other hand, if $f$ is commutable with a quadratic form $x^2-xy+y^2$, then $f$ is one of three kinds of functions: the identity function, the constant function, and an ...
arxiv  

Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny

Molecules
COX-2 plays a key role in converting arachidonic acid into prostaglandins. This makes it a significant target for treating inflammation. Selective COX-2 inhibitors have marked a new phase in inflammatory treatment, providing significant effectiveness ...
Najla A. Alshaye, Mohamed K. Elgohary, Mahmoud S. Elkotamy, Hatem A. Abdel-Aziz   +3 more
doaj   +1 more source

Inhibition of cytosolic Phospholipase A₂ prevents prion peptide-induced neuronal damage and co-localisation with Beta III Tubulin

BMC Neuroscience, 2012
Background Activation of phospholipase A2 (PLA2) and the subsequent metabolism of arachidonic acid (AA) to prostaglandins have been shown to play an important role in neuronal death in neurodegenerative disease.
Last Victoria, Williams Alun, Werling Dirk   +2 more
doaj   +1 more source

Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production [PDF]

Journal of Neuroimmunology 174(1-2): 39-51 (2006), 2007
In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH. Furthermore, in combination with aspirin, ascorbic acid augmented the inhibitory effect of aspirin on PGE2 synthesis. However, ascorbic acid had no synergistic effect along with other
arxiv  

Uniformly bounded components of normality [PDF]

, 2007
Suppose that $f(z)$ is a transcendental entire function and that the Fatou set $F(f)\neq\emptyset$. Set $$B_1(f):=\sup_{U}\frac{\sup_{z\in U}\log(|z|+3)}{\inf_{w\in U}\log(|w|+3)}$$ and $$B_2(f):=\sup_{U}\frac{\sup_{z\in U}\log\log(|z|+30)}{\inf_{w\in U}\log(|w|+3)},$$ where the supremum $\sup_{U}$ is taken over all components of $F(f)$.
arxiv   +1 more source

Efficacy of Foley Catheter Bulb with Intracervical Dinoprostone Gel versus Dinoprostone Gel Alone for Cervical Ripening and Induction of Labour: An Observational Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: One of the most common obstetrical interventions is the induction of labour. Cervical ripening drugs are typically used before conventional methods of induction since they are linked to an increased risk of protracted labour ...
Sohan Bhowmick, Nilratan Das, Tanmoy Das, Arunava Biswas   +3 more
doaj   +1 more source

Truncations and compositions in function spaces [PDF]

arXiv, 2022
These notes deal with some recent assertions about truncations $f \mapsto |f|$ and compositions $f \mapsto g\circ f$ in the spaces $A^s_{p,q}(\mathbb{R}^n)$, $A \in \{B,F \}$.
arxiv  

Almost perfect nonlinear power functions with exponents expressed as fractions [PDF]

arXiv, 2023
Let $F$ be a finite field, let $f$ be a function from $F$ to $F$, and let $a$ be a nonzero element of $F$. The discrete derivative of $f$ in direction $a$ is $\Delta_a f \colon F \to F$ with $(\Delta_a f)(x)=f(x+a)-f(x)$. The differential spectrum of $f$ is the multiset of cardinalities of all the fibers of all the derivatives $\Delta_a f$ as $a$ runs ...
arxiv  

Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum [PDF]

Journal of Molecular Neuroscience 27(3): 303-310 (2005), 2007
Prostaglandin E2 (PGE2), is a major prostanoid produced by the activity of cyclooxygenases (COX) in response to various physiological and pathological stimuli. PGE2 exerts its effects by activating four specific E-type prostanoid receptors (EP1, EP2, EP3, and EP4).
arxiv