Results 101 to 110 of about 120,528 (253)

Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. [PDF]

, 2012
The transcription factors Elk1 and serum response factor (SRF) are central regulators of cell cycle and phenotype in various cell types. Elk1 is activated by phosphorylation (serine-383), while activation of SRF requires its co-factor, myocardin ...
Christian G Stief, Strittmatter, Frank, Martin Hennenberg, Waidelich, Raphaela, Beckmann, Christer, Füllhase, Claudius, Rutz, Beata, Montorsi, Francesco, Petter Hedlund, Christer Beckmann, Christian Gratzke, Stief, Christian Georg, Raphaela Waidelich, Hedlund, Petter, Frank Strittmatter, Karl-Erik Andersson, Andersson, Karl-Erik, Francesco Montorsi, Hennenberg, Martin, Gratzke, Christian, Beata Rutz, Claudius Füllhase   +21 more
core   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Correlation of Transrectal Ultrasonography Guided Prostate Biopsy Gleason Score Results with Prostate Volume in Patients with Prostate Specific Antigen Level Between 2.5-10 ng/mL [PDF]

Objective: To investigate the correlation between prostate volume (PV) and Gleason score (GS) results obtained by systematic transrectal prostate biopsy in patients with a prostate-specific antigen value between 2.5 and 10 ng/mL.
Kazım Erdem, Coşkun Bostancı
core   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Prostate-specific antigen.

The Western journal of medicine, 1992
The Scientific Board of the California Medical Association presents the following inventory of items of progress in urology. Each item, in the judgment of a panel of knowledgeable physicians, has recently become reasonably firmly established, both as to scientific fact and important clinical significance.
openaire   +3 more sources

Effect of Percent Free Prostate-Specific Antigen Measurement on Improving the Specificity of Serum Prostate-Specific Antigen Testing in Taiwanese Patients

, 2009
Background and pu,pose: Measurement of percent free prostate -specific antigen (fPSA) has been shown to enhance the diagnostic performance of traditional serum PSA determination.
LIAO, CHUN-HOU;LIU, SHIH-PING;PU, YEONG-SHIAU;HUANG, CHAO-YUAN;YU, HONG-JENG;CHEN, JUN, 廖俊厚;劉詩彬;蒲永孝;黃昭淵;余宏政;陳淳   +1 more
core  

Prostate‐specific antigen nadir within 12 months of prostate cancer radiotherapy predicts metastasis and death

, 2006
BACKGROUND. The nadir prostate-specific antigen (PSA) at 1 year (nPSA12) was investigated as an early estimate of biochemical and clinical outcome after radiotherapy (RT) alone for localized prostate cancer.
Alcántara Carrió, María Del Pino, Pollack, Alan, Hanlon, Alexandra, Horwitz, Eric, Buyyounouski, Mark   +4 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Correlation of Bacterial Urinary Tract Infection with Prostate Specific Antigen Level in Patients Serum

Kufa Journal for Nursing Sciences, 2014
Objectives: To find out the effect of bacterial urinary tract infection on prostate specific antigen levels in patients serum the secreted by the prostate gland.
Ali Jabbar Abd-Zaid AL-Kilaby, Wasan Sami Hameed   +1 more
doaj   +1 more source

Components of cell-matrix linkage as potential new markers for prostate cancer

, 2011
Prostate cancer is one of the most common tumor diseases worldwide. Often being non-aggressive, prostate tumors in these cases do not need immediate treatment.
Alexey Navdaev, Eble, Johannes A., Navdaev, Alexey, Johannes A. Eble   +3 more
core   +1 more source