Results 121 to 130 of about 8,268,208 (290)

Engineered antibody and neuropeptide mediated radionuclide targeting in prostate cancer [PDF]

, 2010
PhDProstate cancer (PC) is the most common cancer type in men in the western world and to date no definitive stratergy to image PC is avaliable. This thesis explores the possibility of using Prostate Specific Membrane Antigen (PSMA) and Gastrin Releasing
Kashani, Roxana M G, Kashani, Roxana M. G.   +1 more
core   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Epithelial SLC25A20 Deficiency Drives Immunosuppressive Neutrophil Remodeling via ARG1 Palmitoylation to Promote Colorectal Cancer

Advanced Science, EarlyView.
SLC25A20 deficiency in tumor cells compromises mitochondrial LCFA transport, which suppresses FAO and drives compensatory release of palmitic acid‐enriched lipids into the TME. These tumor‐derived palmitic acids are taken up by TANs, promoting ZDHHC18‐catalyzed ARG1 palmitoylation.
Yue Han, Tian‐Yuan Tan, Bin Zhang, Ye‐Bin Fu, Wen Chen, Min‐Hui Yang, Yi‐Qing Wang, Yan‐Qing Ding, Shuang Wang   +8 more
wiley   +1 more source

Epidemiological Study of Patients with Prostate Cancer in South of Iraq

مجلة علوم ذي قار, 2019
The present study was designed to investigate some epidemiological and serological study, in a sample of Thi-Qar, Basarh, Missan provinces south of Iraq.
Manal Badi Salih Al-Tmemi
doaj  

MPP8 Facilitates DNA DSB Repair via NHEJ to Promote Chemoresistance of TNBC Independent of Methyl‐H3K9 Binding

Advanced Science, EarlyView.
Chemoresistance is often linked to elevated DNA repair. MPP8 is found to promote breast cancer chemoresistance as a novel NHEJ accessory factor independent of its epigenetic functions. Through multiple protein interactions, MPP8 facilitates association of DNAPK and ligase complexes to promote DNA repair progression.
Rupa Kumari, Jia Fang
wiley   +1 more source

The Impact of Interscreening Interval and Age on Prostate Cancer Screening With Prostate-Specific Antigen

, 2014
Background: Population-based screening for prostate cancer (PCa) has used serum prostate-specific antigen (PSA) since the early 1990s. However, the efficacy could be affected by screening interval, age ranges of screening, attendance, and contamination ...
Wu, Grace Hui-Min;Auvinen, Anssi;Yen, Amy Ming-Fang;Hakama, Matti;Tammela, Teuvo L.;Stenman, Ulf-Hakan;Kujala, Paula;Ruutu, Mirja;Chen, Hsiu-Hsi, 陳秀熙   +1 more
core   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Correlation of Transrectal Ultrasonography Guided Prostate Biopsy Gleason Score Results with Prostate Volume in Patients with Prostate Specific Antigen Level Between 2.5-10 ng/mL [PDF]

Objective: To investigate the correlation between prostate volume (PV) and Gleason score (GS) results obtained by systematic transrectal prostate biopsy in patients with a prostate-specific antigen value between 2.5 and 10 ng/mL.
Kazım Erdem, Coşkun Bostancı
core   +1 more source

ZMIZ2–DUX4–LGR5 Signaling Axis Maintains Stemness Properties and Facilitates Docetaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study identifies ZMIZ2 as a therapeutic target for docetaxel‐resistant triple‐negative breast cancer, sustaining cancer stemness‐associated properties and docetaxel resistance. ZMIZ2 upregulation enhances DUX4‐mediated LGR5 activation through the SWI/SNF components BRG1 and BAF57.
Xueting Gan, Shulei Sun, Ran Hu, Yuheng Feng, Xinhao Wu, Fangqi Liu, Xuyong Lin, Xiupeng Zhang, Xuezhu Rong, Qiang Han   +9 more
wiley   +1 more source

Neuroendocrine Transformation Without PSA Elevation in High‐Risk Metastatic Castration‐Sensitive Prostate Cancer Under Androgen Receptor Signaling Inhibition: A Case Report

IJU Case Reports
Introduction Neuroendocrine prostate cancer is a rare and highly aggressive variant of prostate cancer with a poor prognosis. We report a case in which metastatic castration‐sensitive prostate cancer directly transformed into neuroendocrine prostate ...
Yoshihiro Nakagami, Shintaro Ohnuma, Masashi Tamaoka, Tatsuki Inoue, Motoki Yamagishi, Kazuhiko Oshinomi, Masakazu Nagata, Yasuyuki Oohira, Toshiko Yamochi, Takashi Fukagai   +9 more
doaj   +1 more source