Results 121 to 130 of about 670,718 (407)

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Systematic review of antitumour efficacy and mechanism of metformin activity in prostate cancer models

BJUI Compass, Volume 4, Issue 1, Page 44-58, January 2023., 2023
Abstract Metformin, the first line pharmacotherapy for type 2 diabetes has demonstrated favourable effects in prostate cancer (PCa) across a range of studies evaluating PCa patient outcomes amongst metformin users. However, a lack of rigorously conducted prospective studies has stalled clinical use in this setting.
Nan Fang Wang, Toni Rose Jue, Jeff Holst, Jennifer H. Gunter   +3 more
wiley   +1 more source

Metastatic prostate cancer in the modern era of PSA screening

International Brazilian Journal of Urology
Introduction To characterize initial presentation and PSA screening status in a contemporary cohort of men treated for metastatic prostate cancer at our institution.
Philip A. Fontenot Jr, Avinash Nehra, William Parker, Hadley Wyre, Moben Mirza, David A. Duchene, Jeffrey Holzbeierlein, James Brantley Thrasher, Peter Van Veldhuizen, Eugene K. Lee   +9 more
doaj   +1 more source

Correlation of Bacterial Urinary Tract Infection with Prostate Specific Antigen Level in Patients Serum

Kufa Journal for Nursing Sciences, 2014
Objectives: To find out the effect of bacterial urinary tract infection on prostate specific antigen levels in patients serum the secreted by the prostate gland.
Ali Jabbar Abd-Zaid AL-Kilaby, Wasan Sami Hameed   +1 more
doaj   +1 more source

A computational study of the statistical mechanics of antibody-antigen conformations [PDF]

arXiv, 2004
We describe the representation of the chemical affinity between the antigen-combining site of the immunoglobulin molecule and the antigen molecule as the probability of the two molecules existing in a bound state. Our model is based on the identification of shape attractors in the configuration space for the joint antibody / antigen combining site ...
arxiv  

Diagnostic image‐based treatment planning for online adaptive ultra‐hypofractionated prostate cancer radiotherapy with MR‐Linac

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose A new workflow was investigated for Elekta Unity MR‐Linac by removing the computed tomography (CT)‐simulation step and using diagnostic CT (DCT) for reference plan generation. Materials and methods Ten patients with ultra‐hypofractionated prostate cancer treated with magnetic resonance imaging (MRI)‐guided adaptive radiotherapy were ...
Yuan Xu, Ningning Lu, Qiao Li, Kuo Men, Xinming Zhao, Jianrong Dai   +5 more
wiley   +1 more source

Percent free prostate-specific antigen is effective to predict prostate biopsy outcome in Chinese men with prostate-specific antigen between 10.1 and 20.0 ng ml−1

Asian Journal of Andrology, 2015
Percent free prostatic-specific antigen (%fPSA) has been introduced as a tool to avoid unnecessary biopsies in patients with a serum PSA level of 4.0-10.0 ng ml−1 , however, it remains controversial whether %fPSA is effective in PSA range of 10.1-20.0 ng
Rui Chen, Li-Qun Zhou, Xiao-Bing Cai, Li-Ping Xie, Yi-Ran Huang, Da-Lin He, Xu Gao, Chuan-Liang Xu, Qiang Ding, Qiang Wei, Chang-Jun Yin, Shan-Cheng Ren, Fu-Bo Wang, Ye Tian, Zhong-Quan Sun, Qiang Fu, Lu-Lin Ma, Jun-Hua Zheng, Zhang-Qun Ye, Ding-Wei Ye, Dan-Feng Xu, Jian-Quan Hou, Ke-Xin Xu, Jian-Lin Yuan, Xin Gao, Chun-Xiao Liu, Tie-Jun Pan, Ying-Hao Sun, on behalf of Chinese Prostate Cancer Consortium   +28 more
doaj   +1 more source

Frequency of KLK3 gene deletions in the general population [PDF]

, 2016
Background One of the kallikrein genes ( KLK3) encodes prostate-specific antigen, a key biomarker for prostate cancer. A number of factors, both genetic and non-genetic, determine variation of serum prostate-specific antigen concentrations in the ...
Alghamdi, Osama, Alharbi, Khalid K, Day, Ian, Gaunt, Tom, Guthrie, Philip, McArdle, Wendy, Rodriguez, Santi, Shihab, Hashem   +7 more
core   +1 more source

A General Theory for Direct Quantitative Analysis of Antigen [PDF]

arXiv, 2011
A theory for direct quantitative analysis of an antigen is proposed. It is based on a potential homogenous immunoreaction system. It establishes an equation to describe the concentration change of the antigen and antibody complex. A maximum point is found in the concentration profile of the complex which can be used to calculate the concentration of ...
arxiv  

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source