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Advanced Molecular Imaging Probes for Skeletal Diseases: Current Progress and Future Perspectives
iRADIOLOGY, EarlyView.This review summarizes the potential molecular imaging techniques and probes for common orthopedic diseases, such as trauma, infection, metabolism, tumor, joint, spine and other fields, aiming to provide a basis for the development of a new generation of molecular imaging probes.
Shuo Guo +6 more
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Seminars in Cancer Biology, 1999
Prostate specific antigen (PSA) is serine protease produced at high concentrations by normal and malignant prostatic epithelium. It is mainly secreted into seminal fluid, where it digests the gel forming after ejaculation. Only minor amounts of PSA leak out into circulation from the normal prostate, but the release of PSA is increased in prostatic ...
U H, Stenman +3 more
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Prostate specific antigen (PSA) is serine protease produced at high concentrations by normal and malignant prostatic epithelium. It is mainly secreted into seminal fluid, where it digests the gel forming after ejaculation. Only minor amounts of PSA leak out into circulation from the normal prostate, but the release of PSA is increased in prostatic ...
U H, Stenman +3 more
openaire +2 more sources
PROSTATE-SPECIFIC ANTIGEN DENSITY
Urologic Clinics of North America, 1997Nearly 20 years have passed since PSA was definitively identified. Throughout this period, its clinical application as a tumor marker has expanded significantly. Today, besides monitoring prostate cancer therapy, PSA is being used extensively in mass screening programs for early detection of adenocarcinoma of the prostate and has become the most ...
M C, Beduschi, J E, Oesterling
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The discovery of prostate‐specific antigen
BJU International, 2007The discovery of prostate‐specific antigen (PSA) was beset with controversy; as PSA is present in prostatic tissue and semen, it was independently discovered and given different names, thus adding to the controversy. In this review we document the early research in this field to describe the chronology of the discovery of PSA.
Amrith Raj, Rao +2 more
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New England Journal of Medicine, 1987
After half a century of clinical application, the usefulness of prostatic acid phosphatase (PAP) as a marker for carcinoma of the prostate is being challenged. Historically the first of the "serum markers" for the presence of a human cancer,1 acid phosphatase is still measured in clinical laboratories all over the world.
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After half a century of clinical application, the usefulness of prostatic acid phosphatase (PAP) as a marker for carcinoma of the prostate is being challenged. Historically the first of the "serum markers" for the presence of a human cancer,1 acid phosphatase is still measured in clinical laboratories all over the world.
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Prostate-specific membrane antigen
The Prostate, 1997In an effort to discover new prostate-specific antigens (PSAs) to enhance our understanding of the functions and behavior of the prostate and the complex processes involved in prostate tumor progression, the structure and function of the PSM antigen has been elucidated.The PSM antigen was recognized using the 7E11-C5.3 monoclonal antibody, generated ...
W R, Fair, R S, Israeli, W D, Heston
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Prostate-Specific Antigen in Urine
European Urology, 1994We investigated concentrations of prostate-specific antigen (PSA) in mid-stream urine of 213 patients. Among them were 34 females. Diagnoses of the male patients were 42 benign prostatic hypertrophy (BPH), 21 localized prostate cancer prior to radical prostatectomy (RP), 15 post-RP without distant or local recurrence, 5 post-RP with local recurrence ...
J, Breul, U, Pickl, R, Hartung
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Purification of a human prostate specific antigen
Journal of Urology, 2002Rabbit antiserum raised against the crude extract of normal human prostatic tissue contained antibodies to a prostatic tissue-specific antigen as shown by immunoprecipitation techniques. Using this antiserum a prostate antigen was detected in normal, benign hypertrophic, and malignant prostatic tissues, but not in other human tissues.
M C, Wang +3 more
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PREDICTING PROSTATE SPECIFIC ANTIGEN OUTCOME PREOPERATIVELY IN THE PROSTATE SPECIFIC ANTIGEN ERA
Journal of Urology, 2001We evaluated the ability of previously defined risk groups to predict prostate specific antigen (PSA) outcome 10 years after radical prostatectomy in patients diagnosed with clinically localized prostate cancer during the PSA era.Between 1989 and 2000, 2,127 men with clinically localized prostate cancer underwent radical prostatectomy, including 1,027 ...
A V, D'Amico +9 more
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The prostate-specific antigen test
Expert Opinion on Medical Diagnostics, 2013Before the 1980s, prostate cancer (PC) was considered a deadly disease. The mortality-incidence ratio showed that 1 out of each 2 - 3 PC patients died of this disease. On the other hand, autopsy studies have shown that latent PC is common in middle-aged men.
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