Radioligand therapy of metastatic castration-resistant prostate cancer: current approaches
Radiation Oncology, 2018 Prostate Cancer is the forth most common type of cancer. Prostate-specific membrane antigen (PSMA) is anchored in the cell membrane of prostate epithelial cells.
Zool Hilmi Awang +2 more
doaj +1 more source
Co-administration of a DNA vaccine encoding the prostate specific membrane antigen and CpG oligodeoxynucleotides suppresses tumor growth [PDF]
, 2004 Background Prostate-specific membrane antigen (PSMA) is a well characterized prostate-specific tumor associated antigen. Its expression is elevated in prostate carcinoma, particularly in metastatic and recurrent lesions.
Zhang Lin +5 more
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Sox7 negatively regulates prostate‐specific membrane antigen (PSMA) expression through PSMA‐enhancer
The Prostate, 2018 BackgroundPSMA expression in the prostate epithelium is controlled by a cis‐element, PSMA enhancer (PSME). PSME contains multiple binding sites for Sox proteins, and in this study, we identified Sox7 protein as a negative regulator of PSMA expression through its interaction with PSME.MethodsThe statistical correlation between Sox7 and PSMA mRNA ...
Wei Peng +7 more
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Therapeutic Advances in Medical Oncology, 2023 The lack of success in prostate cancer from immune checkpoint inhibitors, which is likely multifactorial, has led to the development and investigation of a number of other novel immunotherapeutic techniques, including antibody–drug conjugates, T-cell ...
Felicity C. Martin +2 more
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Towards personalized treatment of prostate cancer: PSMA I&T, a promising prostate-specific membrane antigen-targeted theranostic agent [PDF]
, 2016 Prostate-specific membrane antigen (PSMA) is a well-established target for nuclear imaging and therapy of prostate cancer (PCa). Radiolabeled small-molecule PSMA inhibitors are excellent candidates for PCa theranostics-they rapidly and efficiently ...
Boerman, O.C. (Otto) +10 more
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Cancer Patient T Cells Genetically Targeted to Prostate-Specific Membrane Antigen Specifically Lyse Prostate Cancer Cells and Release Cytokines in Response to Prostate-Specific Membrane Antigen [PDF]
, 1946 The expression of immunoglobulin-based artificial receptors in normal T lymphocytes provides a means to target lymphocytes to cell surface antigens independently of major histocompatibility complex restriction.
Gong, Michael C. +5 more
core +2 more sources
The utility of PSMA and PSA immunohistochemistry in the cytologic diagnosis of metastatic prostate carcinoma [PDF]
, 2013 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107502/1/dc23075 ...
Bernacki, Kurt D. +2 more
core +1 more source
Selection and characterization of Anticalins targeting human prostate-specific membrane antigen (PSMA) [PDF]
Protein Engineering Design and Selection, 2016 Although prostate carcinoma (PCa) is by far the most commonly diagnosed neoplasia in men, corresponding diagnostic and therapeutic modalities have limited efficacy at present. Anticalins comprise a novel class of binding proteins based on a non-immunoglobulin scaffold that can be engineered to specifically address molecular targets of interest. Here we
Cyril, Barinka +5 more
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Editor’s Pick: PSMA-Specific Ligands in Prostate Cancer Diagnosis and Therapy [PDF]
European Medical Journal Urology, 2016 Prostate-specific membrane antigen (PSMA) is the most extensively studied biomarker and antigen of prostate cancer. It is overexpressed in almost all prostate cancers, and the expression level increases with prostate cancer progression.
Wei Jin, Ashutosh Barve, Kun Cheng
doaj
Accuracy of standard clinical 3T prostate MRI for pelvic lymph node staging: Comparison to 68Ga-PSMA PET-CT [PDF]
, 2019 The aim was to assess the performance of prostate 3T MRI for pelvic lymph node (LN) staging in prostate cancer (PCa), in comparison to 68Gallium-prostate specific membrane antigen PET-CT (68Ga-PSMA PET-CT) as reference standard for LN detection.
Brenner, Winfried +6 more
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