Results 51 to 60 of about 21,169 (256)

Total chemical synthesis of PSMA-11: API for 68Ga-PSMA-11 used for prostate cancer diagnosis

European Journal of Medicinal Chemistry Reports, 2021
The imaging of prostate tumours by targeting Prostate Specific Membrane Antigen (PSMA), using binding tracer, 68Ga-PSMA-11, offer lots of promises for specific detection of prostate associated malignancies. The popularity of 68Ga-PSMA-11 as a radioligand
K.S. Ajish Kumar, Anupam Mathur
doaj   +1 more source

In vitro Validierung der in vivo PSMA-Expression in der 68Ga-PSMA-PET/CT beim primären Prostatakarzinom durch die Immunohistochemie [PDF]

, 2019
Eine korrekte Diagnose und ein exaktes Staging sind die Voraussetzungen für das Management und das angemessene Therapiekonzept für Prostatakarzinom-Patienten.
Woythal, Nadine
core   +1 more source

Targeting of radiolabeled J591 antibody to PSMA-expressing tumors: optimization of imaging and therapy based on non-linear compartmental modeling [PDF]

, 2016
BACKGROUND: We applied a non-linear immunokinetic model to quantitatively compare absolute antibody uptake and turnover in subcutaneous LNCaP human prostate cancer (PCa) xenografts of two radiolabeled forms of the humanized anti-prostate-specific ...
Blesida Punzalan, Daniel E. Spratt, Darren R. Veach, Edward K. Fung, Jawaria Amir, Joseph R. Osborne, Neil H. Bander, Pat B. Zanzonico, Sandhya Chalasani, Sarah M. Cheal, Shoaib B. Fareedy, Steven M. Larson, Volkan Beylergil, Wolfgang A. Weber   +13 more
core   +1 more source

Targeted Prostate Biopsy Using 68Gallium PSMA-PET/CT for Image Guidance

Urology Case Reports, 2017
Prostate specific membrane antigen (PSMA) scanning is a sensitive method of prostate cancer detection. In a 71 y.o. man with a PSA of 49 (6%F), 4 negative MRI studies and 6 negative biopsies over an 8 year interval, a 68Ga-PSMA PET/CT scan showed a PSMA ...
Demetrios N. Simopoulos, Shyam Natarajan, Tonye A. Jones, Wolfgang P. Fendler, Anthony E. Sisk, Jr., Leonard S. Marks   +5 more
doaj   +1 more source

Einfluss der 68Ga-HBED-CC PSMA PET/CT auf Diagnostik und Therapiemanagement des Prostatakarzinoms [PDF]

, 2019
Einleitung Die Arbeit analysiert retrospektiv den Einfluss der metabolischen Bildinformation der PET/CT auf das Therapiemanagement von Patienten mit Prostatakarzinom unter Verwendung des neuen Tracers 68Ga-HBED-CC PSMA. Methodik Die Studie wurde durch
Gericke, Maximilian
core   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Cancers and Benign Processes on 68Ga PSMA PET-CT Imaging Other than Prostate Cancer

World Journal of Nuclear Medicine, 2022
Background Imaging plays an important role in the evaluation of prostate cancer patients. In recent years, much attention has been focused on gallium 68 prostate-specific membrane antigen positron emission tomography-computed tomography (68Ga PSMA PET-CT)
Pinar Pelin Ozcan, Mustafa Serdengectı, Zehra Pinar Koc, Yüksel Balcı, Mesut Tek, Murat Bozlu, Erdem Akbay, Vehbi Erçolak   +7 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Intermediate-term outcome after PSMA-PET guided high-dose radiotherapy of recurrent high-risk prostate cancer patients [PDF]

, 2017
Background By the use of PSMA positron emission tomography (PET) detection of prostate cancer lesions with a high sensitivity and specificity combined with a favorable lesion to background contrast is feasible.
Beck, Marcus, Budach, Volker, Furth, Christian, Ghadjar, Pirus, Kaul, David, Rogasch, Julian, Wlodarczyk, Waldemar, Wust, Peter, Zschaeck, Sebastian   +8 more
core   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source