Results 81 to 90 of about 309,069 (202)

Clinical outcomes and costs of robotic surgery in prostate cancer: a multiinstitutional study in Korea [PDF]

, 2019
Background: This study compared the surgical, functional, and oncologic outcomes of robot-assisted laparoscopic radical prostatectomy (RALP), laparoscopic radical prostatectomy (LRP), and retropubic radical prostatectomy (RRP) in Korean men.
나군호
core   +1 more source

Chemosensitization of Human Renal Cell Cancer Using Antisense Oligonucleotides Targeting the Antiapoptotic Gene Clusterin

Neoplasia: An International Journal for Oncology Research, 2001
BACKGROUND: Renal cell cancer (RCC) is a chemoresistant disease with no active chemotherapeutic agent achieving objective response rates higher than 15%.
Tobias Zellweger, Hideaki Miyake, Laura V. July, Majid Akbari, Satoshi Kiyama, Martin E. Gleave   +5 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Prognostic value of a cell cycle progression signature for prostate cancer death in a conservatively managed needle biopsy cohort. [PDF]

, 2012
BACKGROUND: The natural history of prostate cancer is highly variable and it is difficult to predict. We showed previously that a cell cycle progression (CCP) score was a robust predictor of outcome in a conservatively managed cohort diagnosed by ...
Younus, A, Stone, S, M Perry, Mesher, D, A Gutin, J S Lanchbury, Scardino, P, H Møller, A Younus, Gutin, A., J Park, Stone, S., Cuzick, J, D M Berney, Lanchbury, JS, D Mesher, Scardino, P., Mesher, D., J Cuzick, Berney, D. M., Moller, H.; id_orcid, Cuzick, J., Reid, JE, Lanchbury, J. S., Berney, DM, Fisher, G., Perry, M, Transatlantic Prostate Group, P Scardino, S Stone, Foster, C. S., Fisher, G, Møller, H, Foster, CS, Reid, J. E., G Fisher, C S Foster, Younus, A., J E Reid, Park, J., Gutin, A, Park, J, Perry, M.   +42 more
core   +1 more source

Characterization of novel small molecule inhibitors of estrogen receptor-activation function 2 (ER-AF2)

Breast Cancer Research
Up to 40% of patients with estrogen receptor (ER)-positive breast cancer will develop resistance against the majority of current ER-directed therapies.
Jane Foo, Francesco Gentile, Shabnam Massah, Helene Morin, Kriti Singh, Joseph Lee, Jason Smith, Fuqiang Ban, Eric LeBlanc, Robert Young, Natalie Strynadka, Nada Lallous, Artem Cherkasov   +12 more
doaj   +1 more source

Publisher Correction: Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

Nature Communications, 2019
The original version of this Article contained errors in Fig. 7. In panels e and f, the graph titles incorrectly read ‘LNCaP-AdtNs’ and ‘LAPC4-AdtNs’, respectively. These errors have now been corrected in both the PDF and HTML versions of the Article.
Hao Geng, Changhui Xue, Janet Mendonca, Xiao-Xin Sun, Qiong Liu, Patrick N. Reardon, Yingxiao Chen, Kendrick Qian, Vivian Hua, Alice Chen, Freddy Pan, Julia Yuan, Sang Dang, Tomasz M. Beer, Mu-Shui Dai, Sushant K. Kachhap, David Z. Qian   +16 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The prevalence of osteoporosis in men with prostate cancer on androgen deprivation therapy: a systematic review and meta-analysis [PDF]

, 2013
*This abstract is free to read on the publisher's website*\ud \ud \ud Objective\ud \ud Novel imaging techniques for prostate cancer (PCa) are required to improve staging and real-time assessment of therapeutic response.
Cowin, Gary, Lehman, Melanie, Wright, Olivia, Lassemillante, Annie-Claude, Prins, John, Tevz, Gregor, Jovanovic, Lidija, Hollier, Brett G., Hooper, John, Tilley, W., Doi, Suhail, Dunne, Jonathan C., Jordan, T. William, Hendy, Stephen, Nelson, Colleen C., Lai, John, Day, T., Sadowski, Martin, Soekmadji, Carolina, An, Jiyuan, Jindal, S., Hill, Michelle, Stylianou, Nataly, Russell, Pamela J., Nelson, Colleen, Pickering, M., McPherson, Stephen, Russell, Pamela, Wang, Chenwei, Kashyap, Abhishek S., Gunter, Jennifer H., Jovanovic, Lydia, Butler, L., Tse, Brian, Thierry, Benjamin, Philp, L.   +35 more
core   +1 more source

Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

Nature Communications, 2018
Prostate cancer often develops resistance to androgen receptor (AR) targeting drugs. Here, the authors show that, under conditions of hypoxia, AR inhibition via enzalutamide increases the expression of the glycolytic enzyme phosphoglucose isomerase (GPI)
Hao Geng, Changhui Xue, Janet Mendonca, Xiao-Xin Sun, Qiong Liu, Patrick N. Reardon, Yingxiao Chen, Kendrick Qian, Vivian Hua, Alice Chen, Freddy Pan, Julia Yuan, Sang Dang, Tomasz M. Beer, Mu-Shui Dai, Sushant K. Kachhap, David Z. Qian   +16 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source