Results 81 to 90 of about 837,272 (256)
The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine [PDF]
, 2010 <p><b>Background:</b>
Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing ...Page Elizabeth, Donaldson, A., Mitra, A, Stapleton, A., Donaldson, Alan, Douglas, F., Douglas, F, Whitaker Hayley C., Fiona Douglas, Leongamornlert, D., Catherine Mercer, null null, Izatt Louise, Tymrakiewicz, M., Lilja, H, Jhavar, S, Whitaker, Hayley C., Vickers, A., Anne George, Walker, L, Warren, Anne Y., Stapleton, A, David E. Neal, Elizabeth Page, Izatt, Louise, Easton, D., Virginia Clowes, Hans Lilja, Leongamornlert, D, Warren Anne Y., Neal David E., Anne Y. Warren, Lindeman, Geoffrey J., Alan Donaldson, Cooper, C., IMPACT Study Steering Committee, Tucker, Kathy, Evans, DG, Bancroft, E., Whitaker, HC, Blanco, I, Stapleton, Alan, Eeles, Rosalind, Easton, Douglas, Hodgson Shirley, Neal, David E., Blanco, I., Jimmy Lam, Lindeman, G.J., Leongamornlert Daniel, Geoffrey J. Lindeman, Tobias, E.S., Mercer, C, Leongamornlert, Daniel, Saunders, Edward, Lam, Jimmy, Izatt, L, Kirk, J, Clowes, V., Hodgson, Shirley, Douglas Easton, Daniel Leongamornlert, Rubinstein, W.S., Shirley Hodgson, David E Neal, Lisa Walker, Mitchell, G., Kirk, Judy, Ignacio Blanco, Donaldson, A, George, Anne, Eeles, R., D Gareth Evans, Neal, DE, Elizabeth Bancroft, Dorkins, H, Ross-Adams, Helen, Evans, D. Gareth; id_orcid, Bancroft, E, Gillian Mitchell, Rubinstein, WS, Bancroft Elizabeth, Donaldson Alan, Lam, J., Lindeman, GJ, Page, Elizabeth, Ross-Adams, H., Male, A, Kote-Jarai Zsofia, Bancroft, Elizabeth K., George, A., Saunders, E, Tucker Kathy, Saunders, E., Cooper Colin, Huw Dorkins, UK GPCS Collaborators, Tymrakiewicz, M, Walker Lisa, Kote-Jarai, Z., Evans, D. Gareth, Burge, Johanna, Walker, Lisa, Lilja Hans, Clowes Virginia, Rubinstein Wendy S., Evans D. Gareth, Mercer, C., Eeles Rosalind, Burge, J, Page, E, Bancroft, Elizabeth, Ross-Adams, H, Judy Kirk, Hayley C. Whitaker, Dorkins, H., Warren, A.Y., Page, E., Lilja, Hans, Anne Y Warren, Colin Cooper, Rosalind Eeles, D. Gareth Evans, Burge Johanna, Dorkins, Huw, Mitchell Gillian, Lindeman Geoffrey J., Evans, D.G., Anita Mitra, Wendy S Rubinstein, Mercer Catherine, Eeles, R, Geoffrey J Lindeman, Lilja, H., Ross-Adams Helen, Stapleton Alan, Rubinstein, Wendy S., Mitra, A., Hodgson, S., Neal, D.E., Easton, D, Jhavar, S., Alan Stapleton, Mitchell, G, Male, Alison, George Anne, Cooper, C, Wendy S. Rubinstein, Edward Saunders, Jhavar Sameer, Hodgson, S, Cooper, Colin, Helen Ross-Adams, Louise Izatt, Kote-Jarai, Zsofia, Blanco Guillermo, Ignacio, Tucker, K., Male Alison, Malgorzata Tymrakiewicz, Kote-Jarai, Z, Blanco, Ignacio, Saunders, Edward J., Evans, D. G., Johanna Burge, Tucker, K, Saunders Edward, Dorkins Huw, Tymrakiewicz, Malgorzata, Kirk, J., Mitra, Anita, Jhavar, Sameer, Blanco Ignacio, Douglas, Fiona, Mitchell, Gillian, Whitaker, H.C., Male, A., IMPACT Study Collaborators, Alison Male, Sameer Jhavar, Clowes, Virginia, Hayley C Whitaker, Tymrakiewicz Malgorzata, Warren, AY, Kathy Tucker, Zsofia Kote-Jarai, Mitra Anita, Kirk Judy, Mercer, Catherine, Lam, J, George, A, Douglas Fiona, Burge, J., Easton Douglas, Clowes, V, Lam Jimmy, Walker, L., Whitaker, H. C., Izatt, L. +197 morecore +1 more sourcePartial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti +4 morewiley +1 more sourceMechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane +7 morewiley +1 more sourceIrradiation of prostate cancer alters circulating small extracellular vesicle functions
Scientific ReportsIt is known that β1 integrins and a downstream signaling molecule c-Src are upregulated in prostate cancer (PrCa) tissues, are co-expressed in circulating small extracellular vesicles (sEVs) and contribute to cancer progression. Here, we demonstrate that Aejaz Sayeed, Vaughn Garcia, Cecilia E. Verrillo, Rachel M. DeRita, Md Niamat Hossain, Shiv Ram Krishn, Samuel Sey, Christopher D. Shields, Adrian D. Altieri, Qin Liu, Khalid Sossey-Alaoui, William K. Kelly, Lucia R. Languino +12 moredoaj +1 more sourceSupporting Patients With Untreated Prostate Cancer on Active Surveillance: What Causes an Increase in Anxiety During the First 10 Months?
Frontiers in Psychology, 2020 BackgroundThe psychological burden possibly deriving from not immediately undergoing radical treatment for prostate cancer (PCa) could be a potential disadvantage of active surveillance (AS), especially in the eve of some relevant clinical exams [i.e ...Maria Francesca Alvisi, Paola Dordoni, Tiziana Rancati, Barbara Avuzzi, Nicola Nicolai, Fabio Badenchini, Letizia De Luca, Tiziana Magnani, Cristina Marenghi, Julia Menichetti, Villa Silvia, Zollo Fabiana, Salvioni Roberto, Valdagni Riccardo, Valdagni Riccardo, Valdagni Riccardo, Bellardita Lara, the Prostate Cancer Multidisciplinary Clinic Working Group +17 moredoaj +1 more sourceThe VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi +2 morewiley +1 more sourceSilodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. [PDF]
, 2012 The transcription factors Elk1 and serum response factor (SRF) are central regulators of cell cycle and phenotype in various cell types. Elk1 is activated by phosphorylation (serine-383), while activation of SRF requires its co-factor, myocardin ...Christian G Stief, Strittmatter, Frank, Martin Hennenberg, Waidelich, Raphaela, Beckmann, Christer, Füllhase, Claudius, Rutz, Beata, Montorsi, Francesco, Petter Hedlund, Christer Beckmann, Christian Gratzke, Stief, Christian Georg, Raphaela Waidelich, Hedlund, Petter, Frank Strittmatter, Karl-Erik Andersson, Andersson, Karl-Erik, Francesco Montorsi, Hennenberg, Martin, Gratzke, Christian, Beata Rutz, Claudius Füllhase, Hennenberg Martin, Stief Christian G., Waidelich Raphaela, Hedlund Petter, Montorsi Francesco, Gratzke Christian, Rutz Beata, Füllhase Claudius, Beckmann Christer, Strittmatter Frank, Andersson Karl-Erik +32 morecore +1 more sourceProstate cancer research: The next generation; report from the 2019 Coffey‐Holden Prostate Cancer Academy Meeting [PDF]
, 2020 IntroductionThe 2019 Coffey-Holden Prostate Cancer Academy (CHPCA) Meeting, "Prostate Cancer Research: The Next Generation," was held 20 to 23 June, 2019, in Los Angeles, California.MethodsThe CHPCA Meeting is an annual conference held by the Prostate ...Ye, Huihui, Jonathan W. Simons, Quigley, David A, Kenneth J. Pienta, Howard R. Soule, H. Benjamin Larman, Sharp, A, Soule, HR, Leigh Ellis, Sharp, Adam, Adam Sharp, Kaochar, S, David A. Quigley, Ellis, Leigh, Ellis, L, Miyahira, Andrea K, Jennifer Jones, Larman, HB, Huihui Ye, Quigley, DA, Salma Kaochar, Kaochar, Salma, Pienta, KJ, Larman, H Benjamin, Simons, JW, Miyahira, AK, Jones, Jennifer, Soule, Howard R, Andrea K. Miyahira, Pienta, Kenneth J, Jones, J, Ye, H, Simons, Jonathan W +32 morecore +1 more source
