Results 71 to 80 of about 258,151 (309)

The Impact of Interscreening Interval and Age on Prostate Cancer Screening With Prostate-Specific Antigen

, 2014
Background: Population-based screening for prostate cancer (PCa) has used serum prostate-specific antigen (PSA) since the early 1990s. However, the efficacy could be affected by screening interval, age ranges of screening, attendance, and contamination ...
Wu, Grace Hui-Min;Auvinen, Anssi;Yen, Amy Ming-Fang;Hakama, Matti;Tammela, Teuvo L.;Stenman, Ulf-Hakan;Kujala, Paula;Ruutu, Mirja;Chen, Hsiu-Hsi, 陳秀熙   +1 more
core   +1 more source

Developing recombinant overlapping peptides of prostate-specific antigen as vaccine

, 2023
Immunotherapy has become a new approach for prostate cancer (PCa) due to its selectivity and efficacy. With immunogenic properties, PSA has been found to be overexpressed in PCa and its enzymatic activity enhances the growth and progression of PCa cells.
Chan, Song
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Correlation between Serum Prostate-Specific Antigen Level with Pathological Grade and Size of Prostate in Prostate Cancer Patients

SVU - International Journal of Medical Sciences
Background: The most prevalent type of cancer in males is prostate cancer, with bone being the most common location of metastases. Objectives: to examine the connotation among serum prostate-specific antigen levels and the pathological grade and size ...
Gamal A. Alsagheer , Mohamed Mostafa Ali Wahman , Ahmed El-Tamawy Abdelreheem Mohamed   +2 more
doaj   +1 more source

Molecular Profiling of Prostate Cancer Patients [PDF]

, 2009
In the UK, more than 30 000 men are diagnosed annually with prostate cancer (PCa) and about 10 000 men die from it each year. Although several molecular markers have been associated with prostate cancer development and/ or progression, only few of them
Nna, Emmanuel Okechukwu
core  

Prognostic value of a cell cycle progression signature for prostate cancer death in a conservatively managed needle biopsy cohort. [PDF]

, 2012
BACKGROUND: The natural history of prostate cancer is highly variable and it is difficult to predict. We showed previously that a cell cycle progression (CCP) score was a robust predictor of outcome in a conservatively managed cohort diagnosed by ...
Younus, A, Stone, S, M Perry, Mesher, D, A Gutin, J S Lanchbury, Scardino, P, H Møller, A Younus, Gutin, A., J Park, Stone, S., Cuzick, J, D M Berney, Lanchbury, JS, D Mesher, Scardino, P., Mesher, D., J Cuzick, Berney, D. M., Moller, H.; id_orcid, Cuzick, J., Reid, JE, Lanchbury, J. S., Berney, DM, Fisher, G., Perry, M, Transatlantic Prostate Group, P Scardino, S Stone, Foster, C. S., Fisher, G, Møller, H, Foster, CS, Reid, J. E., G Fisher, C S Foster, Younus, A., J E Reid, Park, J., Gutin, A, Park, J, Perry, M.   +42 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Generation and application of recombinant antibody fragments for prostate cancer detection. [PDF]

, 2010
Prostate cancer (PCa) is the most prevalent adenocarcinoma and the second highest cause of cancer-related deaths in men. Early diagnosis is required to identify the development of PCa to reduce the risk of the disease metastasising to different regions ...
Hayes, Conor
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source