Results 101 to 110 of about 9,980,667 (237)
Advanced Science, EarlyView.Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao +5 more
wiley +1 more source
Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control
Advanced Science, EarlyView.Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang +9 more
wiley +1 more source
Urology Journal, 2009 <p><strong>Introduction:</strong> The objective of this study was to evaluate the value of serum prostate-specific antigen (PSA) and prostate-specific antigen density (PSAD) in the diagnosis of prostate cancer.</p><p>< ...
Mahyar Ghafoori +4 more
doaj
Advanced Science, EarlyView.An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei +10 more
wiley +1 more source
Revista Ciencias Biomédicas, 2012 Introduction: Prostate cancer is the second most common cancer in men worldwide, itsincidence has increased by the use of early detection methods such as routine checks,the Prostate Specific Antigen (PSA) and its fractions as a method of screening ...
Benedetti-Padrón Inés +2 more
doaj
Advanced Science, EarlyView.PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang +5 more
wiley +1 more source
, 2014 Background: Population-based screening for prostate cancer (PCa) has used serum prostate-specific antigen (PSA) since the early 1990s. However, the efficacy could be affected by screening interval, age ranges of screening, attendance, and contamination ...
Wu, Grace Hui-Min;Auvinen, Anssi;Yen, Amy Ming-Fang;Hakama, Matti;Tammela, Teuvo L.;Stenman, Ulf-Hakan;Kujala, Paula;Ruutu, Mirja;Chen, Hsiu-Hsi +1 more
core +1 more source
Advanced Science, EarlyView.Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu +12 more
wiley +1 more source
Advanced Science, EarlyView.A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu +4 more
wiley +1 more source
, 2009 Background and pu,pose: Measurement of percent free prostate -specific antigen (fPSA) has been shown to enhance the diagnostic performance of traditional serum PSA determination.
LIAO, CHUN-HOU;LIU, SHIH-PING;PU, YEONG-SHIAU;HUANG, CHAO-YUAN;YU, HONG-JENG;CHEN, JUN +1 more
core