Results 101 to 110 of about 207,050 (299)

Castleman disease mimicking prostate cancer metastasis: diagnostic implications of [68Ga]Ga-PSMA-11 PET/CT

Nuclear Medicine Review
Castleman’s disease is a rare lymphoproliferative disorder that can mimic malignancy in cancer patients. This study presents a rare case of Castleman disease coexisting with prostate cancer, highlighting the potential value of gallium 68-labelled ...
Wioletta Chalewska, Paulina Cegla, Klaudia Zajkowska, Grażyna Łapińska, Marek Dedecjus   +4 more
doaj   +1 more source

68Gallium-prostate-specific membrane antigen ligand positron-emission tomography or computed tomography in biochemical failure after radical prostatectomy: A case report

South African Journal of Oncology, 2017
Biochemical failure after radical treatment for prostate cancer occurs in up to 30% – 50% of cases. Localisation of clinical disease is challenging because clinical symptoms often manifest long after the initial rise in prostate-specific antigen.
Irene A. Chidothe, David B. Anderson
doaj   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Characterizing PSMA heterogeneity in prostate cancer and identifying clinically actionable tumor associated antigens in PSMA negative cases

Scientific Reports
Prostate-specific membrane antigen (PSMA)-targeted theranostics have profoundly reshaped prostate cancer (PCa) management. However, patterns of PSMA expression heterogeneity and the identification of alternative targets for PSMA-negative cases remain ...
Yelin Mulati, Qi Shen, Yuxuan Tian, Yuke Chen, Kaifeng Yao, Wei Yu, Yunpeng Cui, Xuedong Shi, Zhisong He, Qian Zhang, Yu Fan   +10 more
doaj   +1 more source

Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology. [PDF]

, 2017
There has been increased interest in utilizing non-invasive "liquid biopsies" to identify biomarkers for cancer prognosis and monitoring, and to isolate genetic material that can predict response to targeted therapies. Circulating tumor cells (CTCs) have
Che, James, Di Carlo, Dino, Jeffrey, Stefanie S, Kulkarni, Rajan P, Lemaire, Clementine A, Liu, Haiyan E, Matsumoto, Melissa, Pao, Edward, Renier, Corinne, Rettig, Matthew, Sollier-Christen, Elodie, Srivinas, Sandy, Triboulet, Melanie   +12 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

PASD1: a promising target for the immunotherapy of haematological malignancies [PDF]

, 2013
In general, there is a lack of good immunotherapy targets within the spectrum of haematological malignancies. However haematopoietic stem cell transplants and continuing antigen discovery have allowed further insight into how further improvements in ...
Denniss, Frances, Guinn, Barbara-Ann, Khan, Ghazala, Mills, Ken I., Pulford, Karen   +4 more
core   +3 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Prostate-Specific Membrane Antigen Expression in Neovasculature of Glioblastoma Multiforme

Advanced Biomedical Research, 2019
Background: Glioblastoma (GBM) is the most malignant brain tumor with a poor prognosis that can be very difficult to cure, and the current treatment options have no optimal outcomes. Hence, it is essential to find new treatment modalities. Histologically,
Parvin Mahzouni, Mitra Shavakhi
doaj   +1 more source

Cancer biomarkers, and novel techniques for detection [PDF]

, 2017
Technologies for early detection of tumors is critical for better therapy outcome and overall change in cancer survival. These assays must be capable of detecting tumors at early stages in order to prevent metastasis of the tumor and help reduce ...
Jamal, Tameem
core