Results 81 to 90 of about 8,420,293 (249)
Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer
Advanced Science, EarlyView.Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei +19 morewiley +1 more sourceProstate Cancer Information Needs of Australian Gay and Bisexual Men
, 2015 In spite of the vast amount of research into prostate cancer, sexual orientation is not a piece of information that is routinely collected in cancer registries, nor is it usually asked of men who participated in prostate cancer research studies, which ...Mitchell, Anne, Dowsett, Gary W, Wong, W K Tim, O'Keefe, David, Duncan, Duane, Lowe, Anthony +5 morecore Association between DNA methylation of HSPB1 and death in low Gleason score prostate cancer. [PDF]
, 2012 BACKGROUND: Heat shock protein 27 (Hsp-27) encoded by gene HSPB1 is a critical regulator of the behavioral phenotype of human prostate cancer (PCa) cells, enhanced expression being associated with highly aggressive disease and poor clinical outcome.M A Thorat, Beesley, C, Lorincz, AT, Y-J Lu, H Møller, Y Yu, Cuzick, J, D M Berney, Moller, Henrik; id_orcid, N Vasiljević, Ahmad, A S, C Beesley, Moller, H, J Cuzick, Lu, Y-J, Berney, DM, Foster, C S, Thorat, M A, Vasiljević, N, Ahmad, AS, Fisher, G, Møller, H, Foster, CS, A T Lorincz, Yu, Y, G Fisher, C S Foster, A S Ahmad, Lorincz, A T, Thorat, MA, Berney, D M +30 morecore +1 more sourceAptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer
Advanced Science, EarlyView.Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang +8 morewiley +1 more sourceThe association of opium addiction with prostate volume: A cross-sectional study
Addicta: The Turkish Journal on Addictions
Benign prostatic hyperplasia is a condition in which the prostate gland enlarges in a non-cancerous manner. Opioids can decrease prostate-specific antigen levels along with testosterone and can lead to changes in prostate volume.Touraj Ourang, Reza Naseri, Mahbobeh Taheri, Maryam Haghighi Morad, Sara Rahmati Aram, Sina Bayat Shahbazi, Sayed Masoud Hosseini, Zahra Razzaghi, Mohammad Sina Mirjani, Mohammad Reza Ahmadi +9 moredoaj +1 more sourceUDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma
Advanced Science, EarlyView.Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong +13 morewiley +1 more sourceThe rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine [PDF]
, 2010 <p><b>Background:</b>
Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing ...Page Elizabeth, Donaldson, A., Mitra, A, Stapleton, A., Donaldson, Alan, Douglas, F., Douglas, F, Whitaker Hayley C., Fiona Douglas, Leongamornlert, D., Catherine Mercer, null null, Izatt Louise, Tymrakiewicz, M., Lilja, H, Jhavar, S, Whitaker, Hayley C., Vickers, A., Anne George, Walker, L, Warren, Anne Y., Stapleton, A, David E. Neal, Elizabeth Page, Izatt, Louise, Easton, D., Virginia Clowes, Hans Lilja, Leongamornlert, D, Warren Anne Y., Neal David E., Anne Y. Warren, Lindeman, Geoffrey J., Alan Donaldson, Cooper, C., IMPACT Study Steering Committee, Tucker, Kathy, Evans, DG, Bancroft, E., Whitaker, HC, Blanco, I, Stapleton, Alan, Eeles, Rosalind, Easton, Douglas, Hodgson Shirley, Neal, David E., Blanco, I., Jimmy Lam, Lindeman, G.J., Leongamornlert Daniel, Geoffrey J. Lindeman, Tobias, E.S., Mercer, C, Leongamornlert, Daniel, Saunders, Edward, Lam, Jimmy, Izatt, L, Kirk, J, Clowes, V., Hodgson, Shirley, Douglas Easton, Daniel Leongamornlert, Rubinstein, W.S., Shirley Hodgson, David E Neal, Lisa Walker, Mitchell, G., Kirk, Judy, Ignacio Blanco, Donaldson, A, George, Anne, Eeles, R., D Gareth Evans, Neal, DE, Elizabeth Bancroft, Dorkins, H, Ross-Adams, Helen, Evans, D. Gareth; id_orcid, Bancroft, E, Gillian Mitchell, Rubinstein, WS, Bancroft Elizabeth, Donaldson Alan, Lam, J., Lindeman, GJ, Page, Elizabeth, Ross-Adams, H., Male, A, Kote-Jarai Zsofia, Bancroft, Elizabeth K., George, A., Saunders, E, Tucker Kathy, Saunders, E., Cooper Colin, Huw Dorkins, UK GPCS Collaborators, Tymrakiewicz, M, Walker Lisa, Kote-Jarai, Z., Evans, D. Gareth, Burge, Johanna, Walker, Lisa, Lilja Hans, Clowes Virginia, Rubinstein Wendy S., Evans D. Gareth, Mercer, C., Eeles Rosalind, Burge, J, Page, E, Bancroft, Elizabeth, Ross-Adams, H, Judy Kirk, Hayley C. Whitaker, Dorkins, H., Warren, A.Y., Page, E., Lilja, Hans, Anne Y Warren, Colin Cooper, Rosalind Eeles, D. Gareth Evans, Burge Johanna, Dorkins, Huw, Mitchell Gillian, Lindeman Geoffrey J., Evans, D.G., Anita Mitra, Wendy S Rubinstein, Mercer Catherine, Eeles, R, Geoffrey J Lindeman, Lilja, H., Ross-Adams Helen, Stapleton Alan, Rubinstein, Wendy S., Mitra, A., Hodgson, S., Neal, D.E., Easton, D, Jhavar, S., Alan Stapleton, Mitchell, G, Male, Alison, George Anne, Cooper, C, Wendy S. Rubinstein, Edward Saunders, Jhavar Sameer, Hodgson, S, Cooper, Colin, Helen Ross-Adams, Louise Izatt, Kote-Jarai, Zsofia, Blanco Guillermo, Ignacio, Tucker, K., Male Alison, Malgorzata Tymrakiewicz, Kote-Jarai, Z, Blanco, Ignacio, Saunders, Edward J., Evans, D. G., Johanna Burge, Tucker, K, Saunders Edward, Dorkins Huw, Tymrakiewicz, Malgorzata, Kirk, J., Mitra, Anita, Jhavar, Sameer, Blanco Ignacio, Douglas, Fiona, Mitchell, Gillian, Whitaker, H.C., Male, A., IMPACT Study Collaborators, Alison Male, Sameer Jhavar, Clowes, Virginia, Hayley C Whitaker, Tymrakiewicz Malgorzata, Warren, AY, Kathy Tucker, Zsofia Kote-Jarai, Mitra Anita, Kirk Judy, Mercer, Catherine, Lam, J, George, A, Douglas Fiona, Burge, J., Easton Douglas, Clowes, V, Lam Jimmy, Walker, L., Whitaker, H. C., Izatt, L. +197 morecore +1 more sourceToward Prostate Cancer Early Warning with a Self‐Powered Wearable Biosensing Platform Integrated with Machine Learning
Advanced Science, EarlyView.ABSTRACT
Current prostate cancer detection methods remain limited in non‐invasiveness and specificity, prompting interest in urinary biomarkers such as sarcosine. Here, we report a urine‐powered wearable platform for non‐invasive sarcosine detection as a proof‐of‐concept for decentralized early warning.Jing Xu, Hanxiao Chen, Qichen Yuan, Liucun Yin, Yifang Tao, Hong Wang, Yuquan Xue, Delai Fu, Huan Pang, Tie Chong, Li Xue +10 morewiley +1 more sourceAssociation between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data [PDF]
, 2011 Background
Kallikrein 15 (KLK15)/Prostinogen is a plausible candidate for prostate cancer susceptibility. Elevated KLK15 expression has been reported in prostate cancer and it has been described as an unfavorable prognostic marker for the disease ...Artitaya Lophatananon, Judith A Clements, Lophatananon, A, Rahman, Aneela, Marquart, Louise, Joanne Aitken, Kenneth Muir, Kedda, M A, Alexander, K, Gardiner, Robert A., Carson Stephens, Easton, Douglas F, Al Olama, AA, Muir, Ken, Jenny L Donovan, Rahman, A A, Muir, K, Rosalind A Eeles, Hamdy, Freddie C., Olama Ali Amin Al, Aneela A. Rahman, Guy, Michelle, Kedda Mary-Anne, Srinivasan Srilakshmi, Donovan, Jenny L., Stephens, C, Aitken, Joanne, Yaxley, John, Clements, Judith A., Donovan, Jenny L, Hamdy, Freddie C, Al Olama, A A, Srinivasan, S, O'Mara, T, Hamdy, FC, Donovan, JL, Guy Michelle, Louise Marquart, Rahman, AA, Lose Felicity, Kedda, MA, Suzanne Chambers, David E. Neal, A. Rahman, Aneela, F. Easton, Douglas, Lophatananon Artitaya, Chambers Suzanne, Gardiner, R A, A. Clements, Judith, C. Hamdy, Freddie, Batra, J, Easton Douglas F., Neal David E., Clements Judith A., Spurdle, Amanda B., A. Eeles, Rosalind, Spurdle, AB, Neal, David E, Neal, David, Eeles, Rosalind A, Easton, DF, L. Donovan, Jenny, Douglas F. Easton, Stephens Carson, Spurdle, A. B., Easton, D F, A. Gardiner, Robert, Donovan, Jenny, Rosalind A. Eeles, Gardiner, Robert, Clements, J. A., Kote-Jarai, Zsofia, Eeles, Rosalind, Easton, Douglas, Gardiner Robert A., Aitken Joanne, Srilakshmi Srinivasan, Rahman, Aneela A., Neal, David E., Freddie C. Hamdy, Kote-Jarai, Z, Freddie C Hamdy, B. Spurdle, Amanda, Ali Amin Al Olama, Yaxley, J, Rahman Aneela A., Guy, M, Easton, Douglas F., O'Mara, Tracy, Alexander, Kimberly, Spurdle, Amanda B, Chambers, Suzanne, Felicity Lose, Gardiner, Robert A, Donovan, J L, Alexander, Kimberley, Clements, Judith A, Robert A. Gardiner, David E Neal, Judith A. Clements, Clements, JA, Muir Kenneth, Kedda, Mary-Anne, Clements, J A, Gardiner, RA, Clements, Judith, Marquart Louise, Batra, Jyotsna, Al Olama, Ali Amin, Lose, F, Eeles, R A, Srinivasan, Srilakshmi, Neal, D E, Marquart, L, Amanda B Spurdle, Mary-Anne Kedda, Donovan Jenny L., Muir, Kenneth, Aitken, J, Neal, DE, Batra Jyotsna, Lophatananon, Aritaya, Rahman, Aneela A, Robert A Gardiner, Spurdle, A B, Eeles, RA, John Yaxley, O'Mara Tracy, Douglas F Easton, Hamdy, F C, Stephens, Carson, Tracy O'Mara, Michelle Guy, Zsofia Kote-Jarai, Hamdy, Freddie, Spurdle, Amanda, Eeles Rosalind A., Yaxley John, Kote-Jarai Zsofia, Kimberly Alexander, Alexander Kimberly, Aneela A Rahman, Hamdy Freddie C., Spurdle Amanda B., Jenny L. Donovan, E. Neal, David, Amanda B. Spurdle, Lose, Felicity, Jyotsna Batra, Olama, Ali Amin Al, Chambers, S, Eeles, Rosalind A., Lophatananon, Artitaya +152 morecore +2 more sources
