Results 171 to 180 of about 115,427 (296)

Pathological Tumour Volume Percentage as a Quantitative Biomarker of Biological Aggressiveness in High-Risk Prostate Cancer. [PDF]

open access: yesCancers (Basel)
Reman LT   +11 more
europepmc   +1 more source

Rates and Predictors of Persistent LUTS Medication Use After Laser Enucleation of the Prostate

open access: yesLUTS: Lower Urinary Tract Symptoms, Volume 18, Issue 3, May 2026.
ABSTRACT Objectives To assess rates of medication use for lower urinary tract symptoms (LUTS) over time following laser enucleation of the prostate (LEP) and to identify preoperative predictors of persistent use. Methods We retrospectively analyzed 864 LEP patients from an institutional tertiary‐care database (11/2017–05/2023) with available 24‐month ...
Maximilian Filzmayer   +8 more
wiley   +1 more source

Can Tc-99m-PSMA SPECT/CT Be Used as Accessible Alternative for Diagnosis of Biochemically Recurrent Prostate Cancer? A Prospective Study. [PDF]

open access: yesDiagnostics (Basel)
Miloš V   +10 more
europepmc   +1 more source

Assessing inter‐observer variability in prostate and GTV segmentation on mpMRI: A comparison between radiation oncologists and AI‐based method

open access: yesJournal of Applied Clinical Medical Physics, Volume 27, Issue 4, April 2026.
Abstract Background Accurate delineation of the prostate and intraprostatic gross tumor volume (GTV) on multiparametric MRI (mpMRI) is critical for radiation therapy planning, particularly for focal dose escalation strategies. However, interpretation of mpMRI can be challenging and prone to inter‐observer variability, especially among radiation ...
Philippe Dionne   +10 more
wiley   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

open access: yesAdvanced Science, Volume 13, Issue 19, 2 April 2026.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng   +12 more
wiley   +1 more source

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

open access: yesAdvanced Science, Volume 13, Issue 23, 23 April 2026.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang   +12 more
wiley   +1 more source

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