Results 31 to 40 of about 48,381 (244)

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Reducing the number of sutures for vesicourethral anastomosis in radical retropubic prostatectomy

International Brazilian Journal of Urology, 2009
OBJECTIVE: To prospectively evaluate the outcome of using a two-suture technique for the vesicourethral anastomosis (VUA) during radical retropubic prostatectomy (RRP).
Evangelos M. Mazaris, Eleftherios Chatzidarellis, Ioannis M. Varkarakis, Athanasios Dellis, Charalambos Deliveliotis   +4 more
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Socioeconomic status is an independent predictor of biochemical recurrence among patients with prostate cancer who undergo radical prostatectomy

International Brazilian Journal of Urology, 2011
PURPOSE: Socioeconomic status (SES) may influence cancer characteristics and behavior in several aspects. We analyzed PCa characteristics and behavior among low income uninsured men, and compare them to high income patients with health insurance in a ...
Victor Srougi, Alberto A. Antunes, Sabrina T, Reis, Marcos F. Dall'Oglio, Adriano J. Nesrallah, Kátia R. M. Leite, Miguel Srougi   +7 more
doaj   +1 more source

Lessons learned from 12,000 robotic radical prostatectomies: Is the journey as important as the outcome? [PDF]

Investigative and Clinical Urology, 2020
Robotic radical prostatectomy (RARP) is a standardized treatment for localized prostate cancer, which provides better functional outcomes and similar oncological outcomes compared to open approaches.
Sung Gu Kang, Ji Sung Shim, Fikret Onol, K. R. Seetharam Bhat, Vipul R. Patel   +4 more
doaj   +1 more source

Automation of Surgical Workflow Recognition: Unveiling the Surgical Instrument Kinematics that Underly Robot‐Assisted Prostatectomy Procedures

Advanced Intelligent Discovery, EarlyView.
Automated procedural analysis is recognized as one of the major game changers for robotic surgery. Meaning digital analysis needs to replace the manual assessments that set todays standard. Mechanical robotic‐instrument tracking enables the derivation of quantitative kinematic metrics that support behavior‐based workflow segmentation into distinct ...
Kateryna Pirkovets, Matthias N. van Oosterom, Vera A. Ottens, Henk G. van der Poel, Fijs W. B. van Leeuwen   +4 more
wiley   +1 more source

Improved early and late continence following robot‐assisted radical prostatectomy with concurrent bladder neck fascial sling (RoboSling)

BJUI Compass, 2023
Objective To describe a novel RoboSling technique performed at the time of robot‐assisted radical prostatectomy (RARP) and its utility for enhancing urinary function recovery postoperatively.
Scott Leslie, Stuart Jackson, Mark Broe, Danielle C. vanDiepen, Christina Stanislaus, Daniel Steffens, George McClintock, Sia Kim, Nicola Jeffery, Jeremy Fallot, Nariman Ahmadi, Arthur Vasilaras, Paul Sved, Lewis Chan, Ruban Thanigasalam   +14 more
doaj   +1 more source

Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of stress urinary incontinence (SUI) is intimately associated with injury to the external urethral sphincter (EUS). In this study, we established an SUI model induced by double vaginal distension and demonstrated that metformin treatment activated the AMPK signaling in the EUS tissue.
Yuting Xu, Xuhong Li, Alvaro Munoz, Li Jiang, Lihua Huang, Yanhua Zhou, Liping Zhu, Youbo Yang   +7 more
wiley   +1 more source

Surgical technique using AdVance™ Sling placement in the treatment of post-prostatectomy urinary incontinence

International Brazilian Journal of Urology, 2007
OBJECTIVES: To describe and illustrate a new minimally invasive approach to the treatment of male stress urinary incontinence following prostatectomy. SURGICAL TECHNIQUE: Our initial experience consisted of four patients treated with the Advance sling ...
David E. Rapp, W. Stuart Reynolds, Alvaro Lucioni, Gregory T. Bales   +3 more
doaj   +1 more source

Effect of enzalutamide on anticoagulant therapy with edoxaban in patients with prostate cancer

British Journal of Clinical Pharmacology, EarlyView.
Aims Treatment with enzalutamide in prostate cancer is challenging due to its high potential for drug–drug interactions, particularly in the typically older population of patients with frequent comorbidities treated with multiple drugs, such as anticoagulants.
Catharina J. P. Op 't Hoog, Niven Mehra, Anouk van Kleef, Diederik M. Somford, Inge M. van Oort, Alex L. T. Imholz, Paul Hamberg, Nielka P. van Erp, Emmy Boerrigter   +8 more
wiley   +1 more source