Results 41 to 50 of about 115,427 (296)

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer

Current Oncology, 2023
(1) Background: Local therapy is highly promising in a multimodal approach strategy for patients with low-volume metastatic prostate cancer (mPCa).
Takafumi Yanagisawa, Pawel Rajwa, Tatsushi Kawada, Kensuke Bekku, Ekaterina Laukhtina, Markus von Deimling, Muhammad Majdoub, Marcin Chlosta, Pierre I. Karakiewicz, Axel Heidenreich, Takahiro Kimura, Shahrokh F. Shariat   +11 more
doaj   +1 more source

Preoperative prostate health index and %p2PSA as the significant biomarkers of postoperative pathological outcomes of prostate cancer in Korean males: A prospective multi-institutional study [PDF]

Investigative and Clinical Urology, 2020
Purpose: To evaluate the clinical utility of percentage of serum prostate-specific antigen (proPSA) to free PSA (%p2PSA) and the prostate health index (PHI) for predicting aggressive pathological outcomes of radical prostatectomy (RP) in Korean males ...
Hongzoo Park, Sang Wook Lee, Geehyun Song, Tae Wook Kang, Jae Hung Jung, Hyun Chul Chung, Sung Jin Kim, Jong Yeon Park, Tae Young Shin, Jeong Hyun Kim   +9 more
doaj   +1 more source

Automation of Surgical Workflow Recognition: Unveiling the Surgical Instrument Kinematics that Underly Robot‐Assisted Prostatectomy Procedures

Advanced Intelligent Discovery, EarlyView.
Automated procedural analysis is recognized as one of the major game changers for robotic surgery. Meaning digital analysis needs to replace the manual assessments that set todays standard. Mechanical robotic‐instrument tracking enables the derivation of quantitative kinematic metrics that support behavior‐based workflow segmentation into distinct ...
Kateryna Pirkovets, Matthias N. van Oosterom, Vera A. Ottens, Henk G. van der Poel, Fijs W. B. van Leeuwen   +4 more
wiley   +1 more source

Erectile dysfunction as a common complication of radical prostatectomy

Quality in Sport
Prostate cancer is a widespread disorder among older men cured in most cases by radical prostatectomy. Erectile dysfunction, among other sexual disabilities, following a prostatectomy, plays an important role in the quality of life of these patients ...
Jacek Kotuła, Marta Kapler, Magdalena Natalia Mąsior, Karolina Zinkow, Izabella Świerczek   +4 more
doaj   +1 more source

Vesicourethral anastomosis facilitated by a new disposable instrument

International Brazilian Journal of Urology, 2004
The author presents a prototype of a disposable device that enables, in one single movement, the passing of all suture stitches in the urethral stump that will be anastomosed to the bladder or to a neobladder, with the advantage of a regular distribution
Antonio C. Di Piero
doaj   +1 more source

Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of stress urinary incontinence (SUI) is intimately associated with injury to the external urethral sphincter (EUS). In this study, we established an SUI model induced by double vaginal distension and demonstrated that metformin treatment activated the AMPK signaling in the EUS tissue.
Yuting Xu, Xuhong Li, Alvaro Munoz, Li Jiang, Lihua Huang, Yanhua Zhou, Liping Zhu, Youbo Yang   +7 more
wiley   +1 more source

Reducing the number of sutures for vesicourethral anastomosis in radical retropubic prostatectomy

International Brazilian Journal of Urology, 2009
OBJECTIVE: To prospectively evaluate the outcome of using a two-suture technique for the vesicourethral anastomosis (VUA) during radical retropubic prostatectomy (RRP).
Evangelos M. Mazaris, Eleftherios Chatzidarellis, Ioannis M. Varkarakis, Athanasios Dellis, Charalambos Deliveliotis   +4 more
doaj   +1 more source

Positive Surgical Margins in the 10 Most Common Solid Cancers. [PDF]

, 2018
A positive surgical margin (PSM) following cancer resection oftentimes necessitates adjuvant treatments and carries significant financial and prognostic implications.
Califano, Joseph A, Clary, Bryan, Cohen, Ezra EW, Kane, Christopher, Lippman, Scott M, Messer, Karen, Molinolo, Alfredo, Murphy, James D, Nguyen, Quyen T, Orosco, Ryan K, Pang, John, Sacco, Assuntina, Tapia, Viridiana J, Tringale, Kathryn R, Wallace, Anne   +14 more
core   +2 more sources

Comparing the effectiveness of prostate cancer screening protocols: European Association of Urology– and European Randomized Study of Screening for Prostate Cancer–based strategies

International Journal of Cancer, EarlyView.
What's New? Although screening reduces prostate cancer mortality, concerns about overdiagnosis and unnecessary biopsies have given rise to more tailored strategies. The European Association of Urology (EAU) proposed a risk‐adapted screening strategy combining prostate‐specific antigen (PSA)‐based intervals, a risk calculator, and magnetic resonance ...
Zhenwei Yang, Luuk A. van Duuren, Monique J. Roobol, Nicole S. Erler, Dimitris Rizopoulos, Eveline A. M. Heijnsdijk   +5 more
wiley   +1 more source