Results 61 to 70 of about 208,651 (377)

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Survival of patients with prostate cancer and normal PSA levels treated by radical prostatectomy

International Brazilian Journal of Urology, 2005
INTRODUCTION: The unpredictability of prostate cancer has become a daily challenge for the urologist, with different strategies being required to manage these cases.
Marcos F. Dall'oglio, Alexandre Crippa, Alberto A. Antunes, Luciano J. Nesrallah, Katia R. Leite, Miguel Srougi   +5 more
doaj   +1 more source

Bilateral vas deferens suturing to prevent inguinal hernias after radical prostatectomy. [PDF]

BJUI Compass
Abstract Objectives To evaluate the efficacy and safety of bilateral vas deferens sutures in preventing postoperative inguinal hernia after prostatectomy for clinically localized prostate cancer. Materials and Methods This retrospective study included 282 patients with localized prostate cancer who underwent open or laparoscopic radical prostatectomy ...
Hata K, Goto Y, Hashimoto M, Takahashi Y, Takiguchi Y, Iwamoto Y, Saito S, Kawaharada A, Enei Y, Sakanaka K, Takahashi K, Hisakane A, Yamazaki T, Yasue K, Aoki S, Kasai K, Yanagisawa T, Tsuzuki S, Ishii G, Yamamoto T, Sasaki H, Miki J, Shimomura T, Yamada H, Furuta A, Miki K, Kimura T.   +26 more
europepmc   +2 more sources

Price of Prostatectomy [PDF]

BMJ, 1974
Three different urological units found that transurethral prostatectomy required a hospital stay at least one week shorter than open Millin or transvesical prostatectomy. By making transurethral resection more widely available there could be a substantial financial saving; but more surgeons would have to specialize in urology.
G. C. Tresidder, M. Singh, S. Argyrou, J. P. Blandy, J. G. Gow, J. Vinnicombe   +5 more
openaire   +3 more sources

Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility

Advanced Therapeutics, EarlyView.
This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam, Lu Yanjun, Bee Luan Khoo, Tongxu Si, Heng Zou, Mengsu Yang   +5 more
wiley   +1 more source

Diagnosis and Treatment of Post-Prostatectomy Lymphedema: What’s New?

Current Oncology, 2023
Lymphedema is a chronic progressive disorder that significantly compromises patients’ quality of life. In Western countries, it often results from cancer treatment, as in the case of post-radical prostatectomy lymphedema, where it can affect up to 20% of
Lorenzo Maria Giuseppe Bianchi, Giovanni Irmici, Maurizio Cè, Elisa D’Ascoli, Gianmarco Della Pepa, Filippo Di Vita, Omar Casati, Massimo Soresina, Andrea Menozzi, Natallia Khenkina, Michaela Cellina   +10 more
doaj   +1 more source

TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup. [PDF]

, 2017
Purpose: Current clinical parameters do not stratify indolent from aggressive prostate cancer. Aggressive prostate cancer, defined by the progression from localized disease to metastasis, is responsible for the majority of prostate cancer–associated ...
Alshalalfa, Mohammed, Bowden, Michaela, Brown, Myles, Davicioni, Elai, Den, Robert B., Ellis, Leigh, Eng, Kevin H., Erho, Nicholas, Feng, Felix Y., Galbo, Phillip, Goodrich, David W., Gray, Kathryn P., Huang, Ying, Jenkins, Robert B., Karnes, R. Jeffrey, Ku, Sheng-Yu, Labbé, David P., Rosario, Spencer, Ross, Ashley E., Schaeffer, Edward M., Sjöström, Martin, Spratt, Daniel E., Sweeney, Christopher J., Wadosky, Kristine M.   +23 more
core   +2 more sources

Automation of Surgical Workflow Recognition: Unveiling the Surgical Instrument Kinematics that Underly Robot‐Assisted Prostatectomy Procedures

Advanced Intelligent Discovery, EarlyView.
Automated procedural analysis is recognized as one of the major game changers for robotic surgery. Meaning digital analysis needs to replace the manual assessments that set todays standard. Mechanical robotic‐instrument tracking enables the derivation of quantitative kinematic metrics that support behavior‐based workflow segmentation into distinct ...
Kateryna Pirkovets, Matthias N. van Oosterom, Vera A. Ottens, Henk G. van der Poel, Fijs W. B. van Leeuwen   +4 more
wiley   +1 more source

A DWI-based hypoxia model shows robustness in an external prostatectomy cohort

Frontiers in Oncology
IntroductionProstate cancer hypoxia is a negative prognostic biomarker. A promising MRI-based tool to assess hypoxia is the ‘Consumption and Supply based Hypoxia’ (CSH) model based on diffusion-weighted imaging (DWI). The aim of the study was to validate
M. Fernandez Salamanca, T. Hompland, M. Deręgowska-Cylke, H. Van der Poel, H. Van der Poel, E. Bekers, M. A. S. Guimaraes, H. Lyng, H. Lyng, U. A. Van der Heide, I. G. Schoots, I. G. Schoots, P. J. Van Houdt   +12 more
doaj   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, EarlyView.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source