Results 81 to 90 of about 151,127 (351)

The Impact of the Percent of Residual Prostate-Specific Antigen on Metastasis-Free Survival in Patients with Persistent Prostate-Specific Antigen after Radical Prostatectomy

The World Journal of Men's Health, 2023
Purpose: Persistent levels of prostate-specific antigen (PSA) is a poor prognostic factor for recurrence after radical prostatectomy (RP). We investigated the impact of the percentage of residual PSA (%rPSA) [(post-/preoperative PSA)×100], representing
Dan Bee Lee, Jae Yeon Kim, Won Hoon Song, Jong Kil Nam, Hyun Jung Lee, Tae Un Kim, Sung-Woo Park   +6 more
doaj   +1 more source

Androgen receptor phosphorylation status at serine 578 predicts poor outcome in prostate cancer patients [PDF]

, 2016
Purpose: Prostate cancer growth is dependent upon androgen receptor (AR) activation, regulated via phosphorylation. Protein kinase C (PKC) is one kinase that can mediate AR phosphorylation. This study aimed to establish if AR phosphorylation by PKC is of
Edwards, J., Heng, J.S., Horgan, P.G., Leung, H.Y., Patek, S.C., Taylor, B., Underwood, M.A., Willder, J.M.   +7 more
core   +1 more source

Confirmation of BIK and SAMHD1 as Prostate Cancer Susceptibility Genes

The Prostate, EarlyView.
ABSTRACT Background To independently assess data for recently reported genes—BIK, SAMHD1, FAM111A, and AOX1—in which rare variants have been associated with prostate cancer (PCa) risk and aggressiveness. Methods The study included 4448 PCa cases from Johns Hopkins School of Medicine and 103,221 population‐based controls from the Genome Aggregation ...
Christian P. Pavlovich, Jun Wei, Marta Gielzak, Zhuqing Shi, Huy Tran, Annabelle Ashworth, S. Lilly Zheng, Patrick C. Walsh, Jun Luo, Brian T. Helfand, William B. Isaacs, Jianfeng Xu   +11 more
wiley   +1 more source

Survival of patients with prostate cancer and normal PSA levels treated by radical prostatectomy

International Brazilian Journal of Urology, 2005
INTRODUCTION: The unpredictability of prostate cancer has become a daily challenge for the urologist, with different strategies being required to manage these cases.
Marcos F. Dall'oglio, Alexandre Crippa, Alberto A. Antunes, Luciano J. Nesrallah, Katia R. Leite, Miguel Srougi   +5 more
doaj   +1 more source

Robot‐Assisted Salvage Prostatectomy: External Validation of the EAU Selection Criteria and Identification of the Optimal Candidate: A Junior ERUS/YAU Collaborative Study

The Prostate, EarlyView.
ABSTRACT Background EAU guidelines recommend salvage radical prostatectomy (sRP) only in highly selected patients with recurrent prostate cancer in experienced centers. Methods The Junior ERUS/Young Academic Urologist Working Group on Robot‐Assisted Surgery conducted a multicentric project to investigate biochemical recurrence‐free (BCR), metastases ...
Mike Wenzel, Christoph Würnschimmel, Arjun Nathan, Marcio Covas Moschovas, Christian Wagner, Giorgio Calleris, Fabrizio Di Maida, Juan Gomez Rivas, Carlo Andrea Bravi, Ruben De Groote, Federico Piramide, Filippo Turri, Keith Kowalczyk, Gopal Sharma, Iulia Andras, Edward Lambert, Nikolaos Liakos, Danny Darlington, Marco Paciotti, Gabriele Sorce, Philipp Mandel, Antonio Galfano, Senthil Nathan, Giancarlo Marra, Paolo Dell'Oglio, Alexandre Mottrie, Felix K. H. Chun, Vipul Patel, Alberto Breda, Alessandro Larcher, Junior ERUS/EAU‐YAU Working Group on Robot‐Assisted Surgery   +30 more
wiley   +1 more source

The primacy of multiparametric MRI in men with suspected prostate cancer [PDF]

, 2019
Background: Multiparametric MRI (mpMRI) became recognised in investigating those with suspected prostate cancer between 2010 and 2012; in the USA, the preventative task force moratorium on PSA screening was a strong catalyst. In a few short years, it has
Logager, V., Panebianco, V., Richenberg, J., Rouviere, O., Schoots, I. G., Villeirs, G.   +5 more
core   +5 more sources

PROSTest, a Multigene Liquid Biopsy Signature, Effectively Stratifies Patients With High PSA for Prostate Biopsy

The Prostate, EarlyView.
ABSTRACT Background Prostate‐specific antigen (PSA) remains the standard biomarker for prostate cancer (PCa) detection, but its limited specificity—particularly in the 3–10 ng/mL range—leads to overdiagnosis and unnecessary biopsies. Including multiparameteric MRI (mpMRI) helps to reduce the number of PSA‐false‐positive biopsies, but there is still a ...
Kambiz Rahbar, R. David Rosin, Mark Kidd, Abdel B. Halim, Oliver Sartor   +4 more
wiley   +1 more source

Pathology of a Canine Model of Localized Prostate Carcinoma

The Prostate, EarlyView.
ABSTRACT Background Dogs spontaneously develop prostate carcinoma (PC) and share prostate gland anatomy, physiology, and size to men. Over the last 15 years, we have developed and refined a canine model of focal PC to evaluate therapeutic‐diagnostic (theranostic) interventions.
Nathan K. Hoggard, Felipe M. Berg, Marlon R. Szczepaniak, Xinning Wang, Noriko Kantake, Gopalakrishnan Ramamurthy, Li Gong, Eric T. Hostnik, Krishan Kumar, Arijit Ghosh, Dong Luo, Michael V. Knopp, Jill M. Keller, Evan T. Keller, Agata A. Exner, James P. Basilion, Michael F. Tweedle, Thomas J. Rosol   +17 more
wiley   +1 more source

Partial ablation versus radical prostatectomy in intermediate-risk prostate cancer: the PART feasibility RCT

Health Technology Assessment, 2018
Background: Prostate cancer (PCa) is the most common cancer in men in the UK. Patients with intermediate-risk, clinically localised disease are offered radical treatments such as surgery or radiotherapy, which can result in severe side effects.
Freddie C Hamdy, Daisy Elliott, Steffi le Conte, Lucy C Davies, Richéal M Burns, Claire Thomson, Richard Gray, Jane Wolstenholme, Jenny L Donovan, Ray Fitzpatrick, Clare Verrill, Fergus Gleeson, Surjeet Singh, Derek Rosario, James WF Catto, Simon Brewster, Tim Dudderidge, Richard Hindley, Amr Emara, Prasanna Sooriakumaran, Hashim U Ahmed, Tom A Leslie   +21 more
doaj   +1 more source

Diagnostic Value of Micro‐Ultrasound in Identifying Local Recurrence After Radical Prostatectomy

The Prostate, EarlyView.
ABSTRACT Purpose The limited resolution of standard transrectal ultrasound (TRUS) has made it difficult to perform biopsies of the prostate bed in cases of suspected local recurrence following radical prostatectomy. The aim of this study was to benchmark the performance of using high resolution micro‐ultrasound (microUS) in place of standard TRUS for ...
Basil Kaufmann, Manish Choudhary, Ashutosh Maheshwari, Swati Bhardwaj, Adriana Pedraza, Reuben Ben‐David, Asher Mandel, Neeraja Tillu, Vinayak G. Wagaskar, Mani Menon, Michael A. Gorin, Ashutosh K. Tewari   +11 more
wiley   +1 more source