Results 111 to 120 of about 150,306 (248)

Pterostilbene Effect on Inflammatory and Oxidation Markers in Benign Prostatic Hyperplasia Rats Model

Iraqi Journal of Pharmaceutical Sciences
Pterostilbene is a potent anti-inflammatory and antioxidant used to treat benign prostatic hyperplasia, which is brought on by the induction of testosterone propionate.
Mohammed Ridha Jawad, Ghaith Ali Jasim
doaj   +1 more source

Transurethral ultrasound ablation (TULSA) for prostate cancer: a systematic review and meta‐analysis

BJU International, EarlyView.
Objective Our objective was to synthesise evidence on oncological, functional and safety outcomes of magnetic resonance imaging‐guided transurethral ultrasound ablation (TULSA) for primary and recurrent prostate cancer. Methods MEDLINE, Embase, Web of Science and Scopus were systematically searched from inception to July 2025. The primary outcomes were
Eugene Wang, Xinyi Wei, Yajat Dua, Marlon Perera, Jeremy Grummet   +4 more
wiley   +1 more source

Aquablation as salvage therapy for benign prostatic hyperplasia: an international multicentre study

BJU International, EarlyView.
Objective Our objective was to evaluate the safety and effectiveness of Aquablation® as a salvage therapy in patients who underwent prior intervention for benign prostatic hyperplasia (BPH). Materials and Methods We retrospectively analysed 1887 consecutive men from the International Collaborative Aquablation Research Urology Society database between ...
Anouk Leathead, Nick Lee, Adel Arezki, David Bouhadana, Liam Murad, Tarek Benzouak, Iman Sadri, Rosie Foucault, Aalya Hamouda, Jeffrey Sioufi, Ilan Ohana, Joshua Cabral, Margaret Gannon, Gregory Raster, David Nusbaum, Abdulla Alameeri, John Klein, Inderjit Singh, James Kearns, Shawn Marhamati, Alexander Glaser, Brian Helfand, Dean Elterman, Tiago Rodrigues, Kevin C. Zorn   +24 more
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10‐Mediated Angiogenesis

Cancer Science, EarlyView.
MEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Chengyu Wei, Xiangyu Liu, Shimin Hu, Xiaodie Shen, Yingli Liu, Xinxin Qin, Ye Zhou, Jianqi Zheng, Bingke Tian, Jingfang Hong, Yongxia Song, Di Wang, Linlin Peng, Jinxia Ding, Fang Wang, Hui Zhang, Shihao Zhang, Huan Qiu   +17 more
wiley   +1 more source

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

Serum sex steroids, gonadotrophins and sex hormone-binding globulin in prostatic hyperplasia

Annals of Saudi Medicine, 2008
Background: Benign prostatic hyperplasia (BPH) develops in elderly males when serum androgens are relatively lower than in healthy younger males, but it is not well understood whether and how sex steroids are altered in prostatic hyperplasia. It is also
Ansari Mohammad Abdul, Begum Dilruba, Islam Fakhrul   +2 more
doaj  

Observed and expected prevalences for severe vision reduction, prostatic hyperplasia and noninflammatory gynecological problems.

, 2013
Observed and expected prevalences for severe vision reduction, prostatic hyperplasia and noninflammatory gynecological problems.
Ingmar Schäfer (307515)
core   +1 more source

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

Multifocal Epithelioid Hemangioma With FOSB Overexpression

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Epithelioid hemangioma (EH) is a benign vascular tumor that most commonly arises on the skin but may also occur in other anatomical locations, including deep soft tissue, bone, visceral organs, penis, and mucosal sites. A hallmark of EH is overexpression of FOS and FOSB, often resulting from various gene fusions.
Phuong Daniels, Aarush Kumar, Alexa Lum, Izabelle Bermudez, Shannon DeSilva, Jonathan Crane, Kristopher McKay   +6 more
wiley   +1 more source