Results 51 to 60 of about 15,814 (254)

Tailored for Real-World: A Whole Slide Image Classification System Validated on Uncurated Multi-Site Data Emulating the Prospective Pathology Workload. [PDF]

open access: yes, 2020
Standard of care diagnostic procedure for suspected skin cancer is microscopic examination of hematoxylin & eosin stained tissue by a pathologist. Areas of high inter-pathologist discordance and rising biopsy rates necessitate higher efficiency and ...
Ayyagari, Devi   +11 more
core   +1 more source

Diagnostic utility of α-methylacyl CoA racemase (P504S) & HMWCK in morphologically difficult prostate cancer [PDF]

open access: yes, 2010
Background To evaluate the diagnostic utility of alpha-methylacyl CoA racemase (P504S) & HMWCK (34beta E12) in morphologically difficult prostate cancer.
K Kumaresan   +5 more
core   +1 more source

Building a Robust Investigator‐Initiated Platform: The I‐CARE Experience

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Investigator‐initiated studies that include information collected by patients are rising, but limited data is available on patient and investigator experience in this setting. The I‐CARE cohort included patients with inflammatory bowel disease (IBD) monthly collecting clinical information in 15 countries for up to 6 years.
Julien Kirchgesner   +906 more
wiley   +1 more source

The role of transurethral resection of prostatic gland in treatment of prostatic іntraepithelial neoplasia

open access: yesКлінічна хірургія, 2018
Objective. To establish the efficacy of transurethral resection of prostatic gland (TURPG) in patients, suffering prostatic intraepithelial neoplasia (PIN) of central zone. Маterials and methods.
М. P. Melnychuk
doaj   +1 more source

Androgen receptors beyond prostate cancer: an old marker as a new target. [PDF]

open access: yes, 2014
Androgen receptors (ARs) play a critical role in the development of prostate cancer. Targeting ARs results in important salutary effects in this malignancy.
Kurzrock, Razelle   +2 more
core   +2 more sources

Dynamics of the association between circulating levels of miRNA and pancreatic cancer risk through the years prior to pancreatic cancer diagnosis

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Early diagnosis is critical for improving pancreatic ductal adenocarcinoma prognosis, but few biomarkers currently exist. In a case–control study of 1,307 pancreatic cancer cases and matched pairs nested in prospective cohort studies, 13 miRNA–cancer associations were found to change during the blood‐draw‐to‐diagnosis time window.
Hui Cai   +10 more
wiley   +1 more source

Inflammation and Atrophy Precede Prostatic Neoplasia in a PhIP-Induced Rat Model

open access: yesNeoplasia: An International Journal for Oncology Research, 2006
2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) has been implicated as a major mutagenic heterocyclicamine in the human diet and is carcinogenic in the rat prostate.
Alexander D. Borowsky   +5 more
doaj   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

open access: yesMed Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang   +12 more
wiley   +1 more source

The influence of age and the presence of prostate cancer on prostate volume, PSA and PSA density

open access: yesBJU International, EarlyView.
Objective To assess prostate volume (PV) changes with age in symptomatic and asymptomatic men with and without clinically significant prostate cancer (csPCa). In symptomatic patients, we additionally analysed the effect of age and csPCa on PSA and PSA‐density (PSA‐D) and compared these to current National Institute for Health and Care Excellence (NICE)
Jill Rusbridge   +4 more
wiley   +1 more source

Basal cell markers:34BE12 and p63, improving detection of basal cells in atypical prostatic lesions

open access: yesمجله كليه طب الكندي, 2019
Background: The diagnosis of prostatic pathology may be of challenging , as some  difficult and suspected, atypical  cases may lack basal cell layer by routine H&E sections . Antibodies against 34BE12(HMW-CK) and p63 aid the diagnosis of such cases ,
Inas A. Rasheed
doaj   +1 more source

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