Results 91 to 100 of about 54,431 (239)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins
Scientific Reports, 2017 Mamba venoms contain a multiplicity of three-finger fold aminergic toxins known to interact with various α-adrenergic, muscarinic and dopaminergic receptors with different pharmacological profiles.
Guillaume Blanchet +8 more
doaj +1 more source
Domestication et fonction nutrition chez les poissons
INRAE Productions Animales, 2004 L’objectif de cet article est d’évaluer dans quelle mesure l’étude du régime alimentaire des poissons peut indiquer les possibilités et les contraintes liées à leur domestication.
C. CAHU
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Toxins, 2019 Over the two last decades, venom toxins have been explored as alternatives to opioids to treat chronic debilitating pain. At present, approximately 20 potential analgesic toxins, mainly from spider venoms, are known to inhibit with high affinity the NaV1.
Tânia C. Gonçalves +9 more
doaj +1 more source
Chaperons moléculaires et repliement des protéines : L'exemple de certaines protéines de choc thermique [PDF]
, 2005 Des conditions ou agents déstabilisant l'environnement cellulaire altèrent souvent le repliement des protéines. Suivant son intensité, ce phénomène peut induire une agrégation irréversible des protéines et entraîner la mort des cellules.
Arrigo, André-Patrick +1 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Protéines végétales et alimentation durable [PDF]
, 2018 Protéines végétales et alimentation durable.
Salles, Jérôme +9 more
core +2 more sources
Gastroentéropathies avec pertes de protéines [PDF]
, 1994 Le tractus gastro-intestinal joue un rôle important dans l'homéostasie des protéines plasmatiques, aussi bien chez le sujet normal que dans les états pathologiques.
Belaiche, Jacques +2 more
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