Results 81 to 90 of about 54,444 (237)
Vieillissement moléculaire des protéines [PDF]
, 2017 Le vieillissement moléculaire des protéines correspond aux modifications non enzymatiques que subissent celles-ci au cours de leur vie biologique et qui conduisent à l’altération de leurs propriétés structurales et fonctionnelles.
Laëtitia Gorisse +3 more
core +1 more source
Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network
Nature CommunicationsParalogous genes are often functionally redundant for long periods of time. While their functions are preserved, paralogs accumulate cryptic changes in sequence and expression, which could modulate the impact of future mutations through epistasis.
Soham Dibyachintan +5 more
doaj +1 more source
INRAE Productions Animales, 1990 Le but de cet essai était d’étudier l’influence du remplacement d’une partie des protéines du lait par celles du blé ou du maïs, sur la digestibilité de l’aliment et la rétention azotée, chez le veau de boucherie.
R. TOULLEC +4 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Frontiers in Immunology, 2018 Monoclonal antibodies are playing an increasing role in both human and animal health. Different strategies of protein and chemical engineering, including humanization techniques of non-human antibodies were applied successfully to optimize clinical ...
Mathieu Dondelinger +6 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Oligomérisation des protéines humaines et virales à sept domaines transmembranaires [PDF]
, 2012 Les récepteurs couplés aux protéines G (RCPG), aussi appelés protéines à sept domaines transmembranaires (7TM), représentent la plus grande famille de protéines. Elle comprend, chez l’homme, environ 900 membres.
Florence Gbahou +3 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Amélioration des activités insecticides des protéines Vip3 de Bacillus thuringiensis
Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2016 Les protéines Vip3 sont des biopesticides de deuxième génération synthétisées et sécrétées par Bacillus thuringiensis au cours de la phase végétative. Ces protéines, découvertes au milieu des années 1990, présentent un grand intérêt pour lutter contre ...
Sameh SELLAMI +3 more
doaj
Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins
Scientific Reports, 2017 Mamba venoms contain a multiplicity of three-finger fold aminergic toxins known to interact with various α-adrenergic, muscarinic and dopaminergic receptors with different pharmacological profiles.
Guillaume Blanchet +8 more
doaj +1 more source