Results 81 to 90 of about 54,431 (239)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network
Nature CommunicationsParalogous genes are often functionally redundant for long periods of time. While their functions are preserved, paralogs accumulate cryptic changes in sequence and expression, which could modulate the impact of future mutations through epistasis.
Soham Dibyachintan +5 more
doaj +1 more source
INRAE Productions Animales, 2001 La production de protéines (lait, viande, laine, poil) des ruminants peut être limitée par des apports insuffisants en certains acides aminés (AA) appelés pour l’occasion AA limitants.
H. RULQUIN +3 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Frontiers in Immunology, 2018 Monoclonal antibodies are playing an increasing role in both human and animal health. Different strategies of protein and chemical engineering, including humanization techniques of non-human antibodies were applied successfully to optimize clinical ...
Mathieu Dondelinger +6 more
doaj +1 more source
Oligomérisation des protéines humaines et virales à sept domaines transmembranaires [PDF]
, 2012 Les récepteurs couplés aux protéines G (RCPG), aussi appelés protéines à sept domaines transmembranaires (7TM), représentent la plus grande famille de protéines. Elle comprend, chez l’homme, environ 900 membres.
Florence Gbahou +3 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Amélioration des activités insecticides des protéines Vip3 de Bacillus thuringiensis
Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2016 Les protéines Vip3 sont des biopesticides de deuxième génération synthétisées et sécrétées par Bacillus thuringiensis au cours de la phase végétative. Ces protéines, découvertes au milieu des années 1990, présentent un grand intérêt pour lutter contre ...
Sameh SELLAMI +3 more
doaj
Interactions des protéines dans l’eau et aux interfaces hydrophobes Des protéines, de l’eau, de l’air... [PDF]
, 2018 National audienceInteractions des protéines dans l’eau et aux interfaces hydrophobes Des protéines, de l’eau, de l’air....
Pezennec, Stéphane
core