Results 171 to 180 of about 11,335 (243)

HSP70 Interactome-Mediated Proteolysis Targeting Chimera (HSP70-PROTAC) for Ferroptosis-Driven Cancer Treatment. [PDF]

Adv Sci (Weinh)
Dong J, Li Y, Liang H, Wu Z, Wang S, Wang Y, Xu J, Lan Y, Cai M, Pan G, Yang H, Miao K, Chen ZS, Tao F, Ma X, Qin JJ.   +15 more
europepmc   +1 more source

Targeted protein degradation: species, diseases and efficient utilization. [PDF]

J Transl Med
Yue T, He J, Hou J.
europepmc   +1 more source

Integrated computational screen and validation of thalidomide-based PROTACs targeting SARS-CoV-2 main protease. [PDF]

RSC Med Chem
Guo LN, Li YH, Zhu RY, Su N, Shao ZY, Diao H.   +5 more
europepmc   +1 more source

Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC). [PDF]

Elife
Salinas-Rebolledo C, Blesa J, Valenzuela-Nieto G, Schwefel D, López-González Del Rey N, Méndez-Ruette M, Burkhalter J, Carrazana E, Díaz-Tejeda F, Arias Catalán I, Cappelli Leon C, Salvadores N, Bátiz LF, Jara R, Obeso JA, Chana-Cuevas P, Sapkota GP, Rojas-Fernandez A.   +17 more
europepmc   +1 more source

Next-Generation Proteolysis-Targeting Chimeras in Precision Oncology: Multifunctional Designs, Emerging Modalities, and Translational Prospects in Targeted Protein Degradation. [PDF]

Drug Dev Res
Nafie MS, Diab MK, Yassen ASA, Elshamy AM, El Tohamy MR, Tawfik HO, Fahmy SA.   +6 more
europepmc   +1 more source

A breakthrough in NSCLC therapy: targeted protein degradation of CD26 via PROTACs. [PDF]

EBioMedicine
Guan X, Yu XY, Zhang L.
europepmc   +1 more source

Reactive oxygen species-activated bioorthogonal chemistry in living systems enabled by boronate-caged dihydrotetrazines. [PDF]

Nat Commun
Ming D, Zhang J, Mu B, Peng D, Wang Y, Kong Y, Wang W, Chu L, Wang R, Liu L.   +9 more
europepmc   +1 more source

CBL ubiquitin ligase targets translation as a degrader E3. [PDF]

Chem Sci
Wicks AT, Buetow L, Suzuki T, Schmidt T, Lilla S, Macmillan-Jones A, Turney J, Gohlke A, Bushell M, Hock AK, Huang DT.   +10 more
europepmc   +1 more source

Recent advances in targeting protein degradation for tumor immunotherapy. [PDF]

J Hematol Oncol
Li S, Jin Y, Wu H, Yuan H, Zhao J.
europepmc   +1 more source