Results 181 to 190 of about 14,786 (290)

Mechanisms and Design Principles of Proteolysis-Targeting Chimeras and Their Emerging Applications. [PDF]

ACS Pharmacol Transl Sci
Knoll N, Neamati N, Üren A.
europepmc   +1 more source

Bumped pomalidomide-based PROTACs

Communications Chemistry
Pomalidomide is an E3 ligase recruiter exploited by PROTACs to degrade target proteins, but its application is hampered by the off-target degradation of other vital endogenous zinc finger (ZF) proteins. Now, the off-target ZF binding of pomalidomide-based PROTACs is evaluated by a high-throughput imaging screening platform, and minimization of off ...
openaire   +3 more sources

Protacs in oral cancer: degrading oncogenic drivers for next-generation therapy. [PDF]

Front Oral Health
Prasad P, Al Maslamani MJ, Dinislam K, Tasqeruddin S, Shamsi A.   +4 more
europepmc   +1 more source

PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulators. [PDF]

J Enzyme Inhib Med Chem
Periyasamy S, Jarrett T, Truong J, Skouta R.   +3 more
europepmc   +1 more source

Hide and seek: targeting nuclear receptor PXR with inhibitors and PROTACs to improve drug efficacy and safety. [PDF]

Expert Opin Ther Targets
Huber AD, Chen T.
europepmc   +1 more source

BBB-Permeable PROTACs: Where Do We Stand? [PDF]

ACS Med Chem Lett
Francisco S, Apprato G, Rossi Sebastiano M, Ermondi G, Caron G.   +4 more
europepmc   +1 more source

PROTAC-Mediated Ternary Complex Stability with Ricin Toxin A: A Computational Perspective. [PDF]

ACS Omega
Botelho FD, Islam ST, LaPlante SR, Franca TCC.   +3 more
europepmc   +1 more source

Targeting BCL-xL in Myeloid Malignancies: From Inhibitors to PROTAC. [PDF]

J Cell Mol Med
Cilloni D, Ferrando A, Frassoni F.
europepmc   +1 more source

Data-Driven Design of PROTAC Linkers to Improve PROTAC Cell Membrane Permeability. [PDF]

JACS Au
Murakami Y, Ishida S, Cho N, Yuki H, Ohta M, Honma T, Demizu Y, Terayama K.   +7 more
europepmc   +1 more source

PROTAC approaches against drug-resistant EGFR^{C797S/L858R/T790M} mutants: biological evaluation and SAR studies (2020-2025). [PDF]

RSC Med Chem
Kumar A, Sharma V, Kumari P, Kaur R, Bhatia R.   +4 more
europepmc   +1 more source