Results 111 to 120 of about 8,592 (243)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
La predicció de la funció d’una proteïna és un dels problemes més desafiadors en l’era post genomica. El nombre de noves proteïnes identificades ha augmentat exponencialment amb els avenços de les tècniques d’alt rendiment. Encara que, la caracterització
Cartanyà Hueso, Àurea
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Les proteïnes de fase aguda indiquen la gravetat de la sarna sarcòptica en la cabra salvatge [PDF]
, 2016 Les proteïnes de fase aguda (PFA) són proteïnes del sèrum la concentració de les quals pot variar a causa de malalties o estrès. Un estudi ha analitzat la concentració de PFA en cabres salvatges sanes i afectades per la sarna sarcòptica.
Ráez-Bravo, Arián +1 more
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FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Les proteïnes espermàtiques bàsiques (PEB) associades al nucli de les esparmàtides madures i espermatozoides de Lampanyctus crocodilus presenten un patró complex on coexisteixen histones juntament amb dos grups de proteïnes més bàsiques: un primer grup ...
Saperas Plana, Núria +2 more
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Proteïnes prions ajuden els bacteris a sobreviure [PDF]
, 2017 Els prions s'han associat tradicionalment amb greus malalties neurològiques, però aquestes proteïnes, en la seva forma funcional, també poden ser beneficioses pels organismes que els porten.
Pallarès i Goitiz, Irantzu +1 more
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