Results 121 to 130 of about 8,592 (243)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Búsqueda de cavitats en proteïnes pr mitjà del calcul de distàncies entre poli-esferes
, 2011 Se aplica una solución de la robótica móvil a un problema del campo de la biologia. Se consiguen encontrar caminos a través de la estructura de una proteina utilizando como base el cálculo de distancias.
Martí Climent, Héctor
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Paper de les Proteïnes Sinàptiques i l'Exocitosi en els processos de Guia Axonal i Migració [PDF]
, 2013 [cat] La guia axonal i la migració són dos processos similars i crucials per al desenvolupament. Aquests dos elements permeten el correcte posicionament cel•lular i la selecció de dianes essencial per a la funcionalitat posterior del sistema nerviós ...
Ros i Torres, Oriol
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Resposta cel·lular a un mal plegament de proteïnes
Una de les principals línies de recerca del grup és l'estudi del mal plegament i l'agregació de proteïnes relacionades amb la malaltia. Estudien aquest fenomen des d'un punt de vista biofísic, per conèixer les propietats de les proteïnes que estan ...
Sánchez de Groot, Natalia
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FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Aplicació de técniques de cromatografia líquida de proteïnes (fplc) a l'estudi de vins blancs. [PDF]
, 1997 La concentració de proteïnes dels vins blancs és de l'ordre de miligrams per litre. Aquestes proteïnes presenten en el vi càrrega elèctrica positiva degut a que tenen un punt isoelèctric superior al pH del vi.
Canals Bosch, Joan Miquel
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α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source