Results 151 to 160 of about 8,592 (243)

Toxocarose chez un homme de 62 ans atteint d’éosinophilie. [PDF]

CMAJ
Lauriente T, Nicolson H, Merkeley H, Gador AE, Harris DJ.   +4 more
europepmc   +1 more source

Identificació en el timus de fragments de proteïnes diana de malalties autoimmunes

Les malalties autoimmunes es desenvolupen quan els limfòcits T (glòbuls blancs) reconeixen com a estranyes molècules pròpies. El timus és l'òrgan del sistema immune on els limfòcits maduren i aprenen a reconèixer les proteïnes pròpies com a tals ...
Álvarez Angulo, Iñaki
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Amyloïdose cutanée nodulaire localisée consécutive à des injections d’insuline chez une femme de 40 ans. [PDF]

CMAJ
Zhuang M, Vaziri M, Sandhu N.
europepmc   +1 more source

Estudis estructurals dels complexos de les proteïnes HMGA1 i de pèptids sintètics amb oligonucleòtids rics en ATs

, 2010
Les proteïnes HMGA humanes són proteïnes nuclears d’alta mobilitat electroforètica que poden modificar la conformació espacial del DNA, regulant l’expressió de nombrosos gens.
Sánchez Giraldo, Raquel
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Mutational landscape and molecular bases of echinocandin resistance in Saccharomyces cerevisiae. [PDF]

Genetics
Durand R, Torbey AG, Giguere M, Pageau A, Dubé AK, Lagüe P, Landry CR.   +6 more
europepmc   +1 more source

Les mutacions "hha" i "hap": increment de l'expressió de proteïnes heteròlogues clonades a "Escherichia coli"

, 1992
[cat] Els mecanismes de regulació de l'expressió gènica a bactèries, i concretament a "E.coli", han estat àmpliament estudiats, no nomès per la seva importànica per la comprensió del funcionament de la cel.lula bacteriana, sinó també pel seu interès en ...
Madrid Xufré, Cristina
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source