Results 171 to 180 of about 8,592 (243)

2025 update of the Greig Health Record: Part 2-what's controversial? [PDF]

Can Fam Physician
Greig A, Lalani F, Dosman C, Verma A, Sheps J, Javaid N.   +5 more
europepmc   +1 more source

Les proteïnes de fase aguda indiquen la gravetat de la sarna sarcòptica en la cabra salvatge

Les proteïnes de fase aguda (PFA) són proteïnes del sèrum la concentració de les quals pot variar a causa de malalties o estrès. Un estudi ha analitzat la concentració de PFA en cabres salvatges sanes i afectades per la sarna sarcòptica.
López Olvera, Jorge R., Ráez Bravo, Arián   +1 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Neurosarcoïdose se manifestant comme une possible hydrocéphalie à pression normale chez un homme de 71 ans. [PDF]

CMAJ
Al Kharbooshi JYA, Li CMF, Appleton CT, Casserly CS.   +3 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Development of the Canadian food intake screener for adolescents based on Canada's Food Guide 2019 healthy eating recommendations. [PDF]

Int J Behav Nutr Phys Act
Tugault-Lafleur C, Desgreniers V, Bessette G, Kazzi RA, Jacob R, Hernandez K, St-Pierre S, Haines J.   +7 more
europepmc   +1 more source

Tècniques bioinformàtiques aplicades a la modelització i simulació de l'estructura i l'activitat de receptors acoblats a proteïnes G

El receptor de la tirotropina (TSHr) i el receptor de quimiocines CCR5 pertanyen a la família dels receptors acoblats a proteïnes G. Hi ha diverses malalties associades al seu funcionament anòmal, des del desenvolupament de tumors a la tiroide fins a la ...
Olivella, Mireia, Deupí i Corral, Xavier, Pardo Carrasco, Leonardo   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Phosphorylation disrupts the interaction between the intrinsically disordered region of the oncogenic NDRG1 and lipid vesicles. [PDF]

Protein Sci
Carosella N, Pastorello C, Waeytens J, Beniamino Y, Roncassaglia V, Serra L, Raussens V, Mileo E, Ciurli S, Zambelli B.   +9 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source