Results 221 to 230 of about 313,816 (251)

Protease‐activated receptor‐2 downregulation is associated to vitiligo lesions

Pigment Cell & Melanoma Research, 2009
Protease-activated receptors (PARs) are members of the G protein-coupled receptor superfamily that are activated by the proteolytic cleavage of their amino terminal domain. PARs are expressed in several tissues by a variety of cells and are implicated in numerous biologic effects, including coagulation, inflammation, mitogenesis and cell proliferation.
Moretti S, Nassini R, Prignano F, Pacini A, Materazzi S, Naldini A, Simoni A, Baroni G, Pellerito S, FILIPPI, ILARIA, Lotti T, Geppetti P, Massi D.   +12 more
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Novel Agonists and Antagonists for Human Protease Activated Receptor 2

Journal of Medicinal Chemistry, 2010
Human protease activated receptor 2 (PAR2) is a G protein-coupled receptor that is associated with inflammatory diseases and cancers. PAR2 is activated by serine proteases that cleave its N-terminus and by synthetic peptides corresponding to the new N-terminus.
Barry, Grant D., Suen, Jacky Y., Le, Giang T., Cotterell, Adam, Reid, Robert C., Fairlie, David P.   +5 more
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Agonists and Antagonists of Protease Activated Receptor-2 (PAR2)

2023
This thesis reports the rational design and development of novel agonists and antagonists for protease activated receptor-2 (PAR2). PAR2 has been implicated in the progression of numerous inflammatory and proliferative diseases, and is upregulated in response to several inflammatory mediators.
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Protease-activated receptor-2 (PAR-2) in cervical cancer proliferation

Gynecologic Oncology, 2008
Protease-activated receptor-2 (PAR-2) is a G-protein-coupled receptor that is cleaved and activated by trypsin and tryptase. There is evidence that PAR-2 contributes to tumor progression in stomach, colon, pancreas, prostate and breast cancer patients. However, the role of PAR-2 in cervical cancer is still unknown. The aim of this work was to study the
Pedro Ernesto, Sánchez-Hernández, Maria Guadalupe, Ramirez-Dueñas, Benibelks, Albarran-Somoza, Trinidad, García-Iglesias, Alicia, del Toro-Arreola, Ramón, Franco-Topete, Adrian, Daneri-Navarro   +6 more
openaire   +2 more sources

Expression of protease activated receptor-2 (PAR-2) in gastric cancer

Journal of Surgical Oncology, 2006
Recently, the four-kind cloning of the protease-activated receptor (PAR) had been carried out. PAR-2 is activated by trypsin and it is supposed that PAR-2 participated in proliferation of the endothelial cell or in neovascularization. We considered whether the expression of PAR-2 has relevance to progression in gastric cancer.Immunohistochemical study ...
Daisuke, Fujimoto, Yasuo, Hirono, Takanori, Goi, Kanji, Katayama, Kazuo, Hirose, Akio, Yamaguchi   +5 more
openaire   +2 more sources

Protease-activated Receptor-2 (par ₂ ) in Human Periodontitis

Journal of Dental Research, 2010
No evidence for the role of protease-activated receptor-2 (PAR 2 ) in human periodontal disease has been demonstrated so far. Thus, we sought to investigate the expression of PAR 2 mRNA in chronic periodontitis, and to examine whether its expression is ...
M, Holzhausen, J R, Cortelli, V Araújo, da Silva, G C Nobre, Franco, S Cavalca, Cortelli, N, Vergnolle   +5 more
openaire   +2 more sources

Modulating Protease-Activated Receptor 2

2018
Protease-activated receptor 2 (PAR2) is a G-protein coupled receptor that is unusual in being activated by proteases. Enzymes such as trypsin, tryptase and factor VIIa cleave the extracellular N-terminal domain of PAR2 at a specific site to expose a new N-terminal “tethered ligand”.
openaire   +3 more sources

Protease activated receptor-2 (PAR2): possible target of phytochemicals

Journal of Biomolecular Structure and Dynamics, 2014
The use of phytochemicals either singly or in combination with other anticancer drugs comes with an advantage of less toxicity and minimal side effects. Signaling pathways play central role in cell cycle, cell growth, metabolism, etc. Thus, the identification of phytochemicals with promising antagonistic effect on the receptor/s playing key role in ...
Kavita Kumari, Kakarala, Kaiser, Jamil
openaire   +2 more sources

Role of Protease-activated Receptor-2 in Idiopathic Pulmonary Fibrosis

American Journal of Respiratory and Critical Care Medicine, 2011
Abstract Rationale Activation of the coagulation cascade has been demonstrated in pulmonary fibrosis. In addition to its procoagulant function, various coagulation proteases exhibit cellular effects that may also contribute to fibrotic processes in the lung.
Malgorzata, Wygrecka, Grazyna, Kwapiszewska, Ewa, Jablonska, Susanne, von Gerlach, Ingrid, Henneke, Dariusz, Zakrzewicz, Andreas, Guenther, Klaus T, Preissner, Philipp, Markart   +8 more
openaire   +2 more sources

Structures of peptide agonists for human protease activated receptor 2

Bioorganic & Medicinal Chemistry Letters, 2012
Protease activated receptor 2 (PAR2) is an unusual G-protein coupled receptor in being self-activated, after pruning of the N-terminus by serine proteases like trypsin and tryptase. Short synthetic peptides corresponding to the newly exposed N-terminal hexapeptide sequence also activate PAR2 on immunoinflammatory, cancer and many normal cell types.
Stoermer, Martin J., Flanagan, Bernadine, Beyer, Renée L., Madala, Praveen K., Fairlie, David P.   +4 more
openaire   +5 more sources