Results 231 to 240 of about 313,816 (251)

Evaluation of protease‐activated receptor 2 in murine models of arthritis

Arthritis & Rheumatism, 2007
AbstractObjectiveProtease‐activated receptor 2 (PAR‐2) activation has been linked to pro‐ and antiinflammatory cellular responses. We undertook this study to explore the importance of PAR‐2 activation in 4 murine models of arthritis and to analyze the expression of PAR‐2 in human arthritic synovium.MethodsZymosan‐induced arthritis (ZIA), K/BxN serum ...
Busso N, Frasnelli M, Feifel R, Cenni B, Steinhoff M, Hamilton J, So A   +6 more
openaire   +3 more sources

Structural insight into allosteric modulation of protease-activated receptor 2

Nature, 2017
Protease-activated receptors (PARs) are a family of G-protein-coupled receptors (GPCRs) that are irreversibly activated by proteolytic cleavage of the N terminus, which unmasks a tethered peptide ligand that binds and activates the transmembrane receptor domain, eliciting a cellular cascade in response to inflammatory signals and other stimuli.
Robert K Y, Cheng, Cédric, Fiez-Vandal, Oliver, Schlenker, Karl, Edman, Birte, Aggeler, Dean G, Brown, Giles A, Brown, Robert M, Cooke, Christoph E, Dumelin, Andrew S, Doré, Stefan, Geschwindner, Christoph, Grebner, Nils-Olov, Hermansson, Ali, Jazayeri, Patrik, Johansson, Louis, Leong, Rudi, Prihandoko, Mathieu, Rappas, Holly, Soutter, Arjan, Snijder, Linda, Sundström, Benjamin, Tehan, Peter, Thornton, Dawn, Troast, Giselle, Wiggin, Andrei, Zhukov, Fiona H, Marshall, Niek, Dekker   +27 more
openaire   +2 more sources

Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins

Proceedings of the National Academy of Sciences of the United States of America, 2011
Andrew Bohm, Lidija Covic, Athan Kuliopulos   +2 more
exaly  

Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E–Deficient Mice

Circulation, 2018
Tomoya Hara, Pham Tran Phuong, Chie Murata   +2 more
exaly  

Protease-activated Receptor-2 (par 2 ) in Human Periodontitis

Journal of Dental Research, 2010
Marinella Holzhausen, Nathalie Vergnolle   +1 more
exaly  

Protease activated receptor 2 (PAR2) modulators: a patent review (2010–2015)

Expert Opinion on Therapeutic Patents, 2016
Mei-Kwan Yau, Junxian Lim, Ligong Liu
exaly  

Protease-Activated Receptor 2, a Receptor Involved in Melanosome Transfer, is Upregulated in Human Skin by Ultraviolet Irradiation

Journal of Investigative Dermatology, 2001
Glynis Scott, Cristina Rodríguez-Burford, Miri Seiberg   +2 more
exaly  

Protease-activated receptor signalling by coagulation proteases in endothelial cells

Thrombosis and Haemostasis, 2014
Alireza R Rezaie
exaly  

Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis☆

Gastroenterology, 2004
Wan Namkung, Xiang Luo, Shmuel Muallem   +2 more
exaly  

Therapeutic potential of protease-activated receptor-1 antagonists

Expert Opinion on Investigational Drugs, 2003
Claudia K Derian, Han-Cheng Zhang, Patricia Andrade-Gordon   +2 more
exaly