Results 151 to 160 of about 211,038 (237)

Neuron-generated thrombin induces a protective astrocyte response via protease activated receptors. [PDF]

Glia, 2020
Rajput PS, Lamb J, Kothari S, Pereira B, Soetkamp D, Wang Y, Tang J, Van Eyk JE, Mullins ES, Lyden PD.   +9 more
europepmc   +1 more source

Few‐Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell‐Like Phenotypes

Advanced Healthcare Materials, EarlyView.
Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar, Peifu Cheng, Tugce Dogruel, Maxsam Donta, Juhyung Jung, Naomi A. Asante, Donald S. Sakaguchi, Surya K. Mallapragada, Piran R. Kidambi, Metin Uz   +9 more
wiley   +1 more source

Novel Function for Endothelial Protease-Activated Receptors in Modulating Insulin Receptor Activity With Implications for Diabetes. [PDF]

Arterioscler Thromb Vasc Biol
Rajala R, Griffin CT.
europepmc   +1 more source

Supplementary Figure 17 from Preclinical Development of SGN-CD47M: Protease-Activated Antibody Technology Enables Selective Tumor Targeting of the Innate Immune Checkpoint Receptor CD47

Matthew R. Levengood, Christopher M. Carosino, Xinqun Zhang, Sasha Lucas, David J. Ortiz, Lori Westendorf, Alice Chin, Arlan D. Martin, Abbie Wong, Shawna Hengel, Hao Sun, Weiping Zeng, Roma Yumul, Melissa M.C. Dominguez, Yufei Chen, Janet H. Zheng, Caroline Karlsson, Vivian H. Trang, Peter D. Senter, Shyra J. Gardai   +19 more
openalex   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

Mucosal sensitization to German cockroach involves protease-activated receptor-2 [PDF]

, 2010
Kristen Page, John R. Ledford, Ping Zhou, Krista Dienger, Marsha Wills‐Karp   +4 more
openalex   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy

, 2019
Michael M. Miller, Jacques Banville, Todd J. Friends, Mark Gagnon, Jon J. Hangeland, Jean-François Lavallée, Alain Martel, Harold R. O'Grady, Roger Rémillard, Edward H. Ruediger, François Tremblay, Shana Posy, Nick J. Allegretto, Victor R. Guarino, David Harden, Timothy W. Harper, Karen S. Hartl, Jonathan L. Josephs, Sarah E. Malmstrom, Carol A. Watson, Yanou Yang, Ge Zhang, Pancras C. Wong, Jing Yang, Michel Bouvier, Dietmar Seiffert, Ruth R. Wexler, R. Michael Lawrence, E. Scott Priestley, Anne Marinier   +29 more
openalex   +1 more source

Thrombin Stimulation of Proteoglycan Synthesis in Vascular Smooth Muscle Is Mediated by Protease-activated Receptor-1 Transactivation of the Transforming Growth Factor β Type I Receptor [PDF]

, 2010
Micah L. Burch, Mandy L. Ballinger, Sundy N.Y. Yang, Robel Getachew, Catherine Itman, Kate L. Loveland, Narin Osman, Peter J. Little   +7 more
openalex   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source