Results 91 to 100 of about 1,749,266 (388)

Plant Kunitz Inhibitors and Their Interaction with Proteases: Current and Potential Pharmacological Targets [PDF]

, 2022
Camila Ramalho Bonturi, Ana Beatriz da Silva Teixeira, Vitória Morais Rocha, Penélope Ferreira Valente, Juliana Rodrigues Oliveira, Clóvis Macêdo Bezerra Filho, Isabel de Fátima Correia Batista, Maria Luiza Vilela Oliva   +7 more
openalex   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Identification of Theaflavin-3,3’-Digallate as a Novel Zika Virus Protease Inhibitor

Frontiers in Pharmacology, 2020
Mounting evidence indicates that Zika virus (ZIKV) is closely related to neurological disorders such as microcephaly and Guillain-Barré syndrome. There are currently no effective vaccines and FDA-approved inhibitors against ZIKV infection. The flaviviral
Xiangling Cui, Rui Zhou, Chenchao Huang, Chenchao Huang, Rongyu Zhang, Rongyu Zhang, Jing Wang, Yongxin Zhang, Jiwei Ding, Jiwei Ding, Xiaoyu Li, Jinming Zhou, Jinming Zhou, Jinming Zhou, Shan Cen, Shan Cen, Shan Cen   +16 more
doaj   +1 more source

Enzymatic Digestion of Calf Fleshing Meat By-Products: Antioxidant and Anti-Tyrosinase Activity of Protein Hydrolysates, and Identification of Fatty Acids

Foods, 2021
The food waste reduction through an efficient recovery of its valuable building molecules has become an important topic with a positive effect on the economy and the environment.
Tullia Tedeschi, Cecilia Anzani, Maura Ferri, Silvia Marzocchi, Maria Fiorenza Caboni, Stefania Monari, Annalisa Tassoni   +6 more
doaj   +1 more source

Neural Network and Bioinformatic Methods for Predicting HIV-1 Protease Inhibitor Resistance [PDF]

, 2007
This article presents a new method for predicting viral resistance to seven protease inhibitors from the HIV-1 genotype, and for identifying the positions in the protease gene at which the specific nature of the mutation affects resistance.
Carpenter, Gail A., Woods, Matthew
core   +1 more source

Identification of medicinal plant-based phytochemicals as a potential inhibitor for SARS-CoV-2 main protease (Mpro) using molecular docking and deep learning methods [PDF]

, 2023
Alomgir Hossain, Md. Ekhtiar Rahman, Md Siddiqur Rahman, Khondokar Nasirujjaman, Mohammad Nurul Matin, Md Omar Faruqe, Muhammad Fazle Rabbee   +6 more
openalex   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Pentamidine inhibition of streptopain attenuates Streptococcus pyogenes virulence

Microbiology Spectrum
The obligate human pathogen Streptococcus pyogenes (also known as GAS; Group A Streptococcus) carries high morbidity and mortality, primarily in impoverished or resource-poor regions. The failure rate of monotherapy with conventional antibiotics is high,
Keya Trivedi, Christopher N. LaRock
doaj   +1 more source

Enzymatic and Non-Enzymatic Virulence Activities of Dermatophytes on Solid Media [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Dermatophytes are keratinophilic fungi causing superficial cutaneous infections that account 20-25% of the global population. As per literature search, there is a dearth in the study on virulence factors of dermatophytes from the Indian
Elangovan Elavarashi, Anupma Jyoti Kindo, Sudha Rangarajan   +2 more
doaj   +1 more source

A neutrophil-dependent pathway for the generation of a neutral peptide mediator: partial characterization of components and control by alpha-1-antitrypsin. [PDF]

, 1974
A biologically active neutral peptide mediator is cleaved from a plasma protein substrate by an alpha-1-antitrypsin-inhibitable serine protease apparently residing on the membrane of the human neutrophil. The peptide mediator has an approximate mol wt of
Austen, KF, Goetzl, EJ, Wintroub, BU
core