Results 91 to 100 of about 580,293 (310)
Role of salivary leukocyte protease inhibitor in periodontal disease progression
Journal of Indian Society of Periodontology, 2010 Context: Proteases play a major role in the tissue destruction involved in periodontal disease. It is known that the balance between proteases and their inhibitors is a major determinant in maintaining tissue integrity.
Pateel Deepak, Seema H, Kale Akla
doaj
Pharmacokinetic Enhancers (Boosters)—Escort for Drugs against Degrading Enzymes and Beyond
Scientia Pharmaceutica, 2018 Pharmacokinetic enhancers (boosters) are compounds used in combination with a primary therapeutic agent (drug) and are not used for their direct effects on the disease but because they enhance or restore the activity of the primary agent.
Jürgen Krauß, Franz Bracher
doaj +1 more source
Optimization of Production Protocol of Alkaline Protease by Streptomyces pulvereceus [PDF]
arXiv, 2010 Extra cellular alkaline protease producing species is an isolate from soil which was characterized and identified as Streptomyces pulvereceus MTCC 8374. Studies on submerged fermentation revealed that maximum level of enzyme production was during early stationary phase.
arxiv
Drug Repurposing Targeting COVID-19 3CL Protease using Molecular Docking and Machine Learning Regression Approach [PDF]
arXiv, 2023 The COVID-19 pandemic has initiated a global health emergency, with an exigent need for effective cure. Progressively, drug repurposing is emerging a promise solution as it saves the time, cost and labor. However, the number of drug candidates that have been identified as being repurposed for the treatment of COVID-19 are still insufficient, so more ...
arxiv
Primary Care Update for OB/GYNS, 2001 With the advent of newer antiretroviral agents for the treatment of patients with human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS), health care providers are faced with many options to optimize their patients' therapy.
College of Medicine, University of Florida, Gainesville, Florida, USA ( host institution ) +1 more
openaire +4 more sources
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source
Proteomes, 2018 Acute myeloid leukemia (AML) is a heterogeneous disease, and communication between leukemic cells and their neighboring leukemia-supporting normal cells is involved in leukemogenesis.
Elise Aasebø +5 more
doaj +1 more source
Inhibition of the Main Protease 3CL-pro of the Coronavirus Disease 19 via Structure-Based Ligand Design and Molecular Modeling [PDF]
arXiv, 2020 We have applied a computational strategy, based on the synergy of virtual screening, docking and molecular dynamics techniques, aimed at identifying possible lead compounds for the non-covalent inhibition of the main protease 3CL-pro of the SARS-Cov2 Coronavirus.
arxiv
How conformational changes can affect catalysis, inhibition and drug resistance of enzymes with induced-fit binding mechanism such as the HIV-1 protease [PDF]
, 2013 A central question is how the conformational changes of proteins affect their function and the inhibition of this function by drug molecules. Many enzymes change from an open to a closed conformation upon binding of substrate or inhibitor molecules.
arxiv +1 more source
Neural Network and Bioinformatic Methods for Predicting HIV-1 Protease Inhibitor Resistance [PDF]
, 2007 This article presents a new method for predicting viral resistance to seven protease inhibitors from the HIV-1 genotype, and for identifying the positions in the protease gene at which the specific nature of the mutation affects resistance.
Carpenter, Gail A., Woods, Matthew
core +1 more source