Results 171 to 180 of about 1,749,266 (388)

Generic protease detection technology for monitoring periodontal disease

, 2011
Periodontal diseases are inflammatory conditions that affect the supporting tissues of teeth and can lead to destruction of the bone support and ultimately tooth loss if untreated.
Cook, Joseph P., Douglas, Ian, Krause, Steffi, Rawlinson, Andrew, Watkinson, Michael, Yang, Shoufeng, Zheng, Xinwei   +6 more
core   +1 more source

"Maturation of the SARS-CoV-2 virus is regulated by dimerization of its main protease" TPR files

, 2021
Shreyas Kaptan, Mykhailo Girych, Giray Enkavi, Waldemar Kulig, Vivek Sharma, Joni Vuorio, Tomasz Róg, Ilpo Vattulainen   +7 more
openalex   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Supplementary Figure S9 from Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis

, 2023
Yoshimi Endo Greer, Lídia Hernandez, Emily M.J. Fennell, Manjari Kundu, Donna Voeller, Raj Chari, Samuel F. Gilbert, Thomas S.K. Gilbert, Shashikala Ratnayake, Binwu Tang, Markus Hafner, Qingrong Chen, Daoud Meerzaman, Edwin J. Iwanowicz, Christina M. Annunziata, Lee M. Graves, Stanley Lipkowitz   +16 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Complexos enzimáticos sobre a energia metabolizável e digestibilidade dos nutrientes do milheto para frangos de corte

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
RESUMO Objetivou-se avaliar o efeito de complexos enzimáticos sobre a energia metabolizável e o coeficiente de digestibilidade de nutrientes do milheto para frangos de corte.
F.A.S. Moura, L.R.B. Dourado, L.A. Farias, J.B. Lopes, S.B.P. Lima, M.L. Fernandes   +5 more
doaj   +1 more source

Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1 [PDF]

, 2008
Donald B. Carter, Edwige Dunn, Adele M. Pauley, Denise D. McKinley, Timothy J. Fleck, Brenda R Ellerbrook, Nancy C. Stratman, Xiangdong Zhou, Carol S. Himes, Jeffrey S. Nye, Alfredo G. Tomasselli, Riqiang Yan   +11 more
openalex   +1 more source

PB2665: THROMBOTIC PROFILE OF A SERIE OF 14 PATIENTS CARRYING 67ARG>STOP POLYMORPHISM IN THE SERPINE A10 (PROTEASE-DEPENDENT PROTEIN Z INHIBITOR) GENE

, 2023
Nuria Bermejo, Verónica Casado-Cabanillas, José María González-Valero, Víctor Higuero, Fatima Ibañez Espacio   +4 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease Models

EBioMedicine, 2016
Christoph Becker-Pauly, Claus U. Pietrzik   +1 more
doaj   +1 more source