Results 231 to 240 of about 1,749,266 (388)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Structural insights into the antiviral efficacy of AG7404 against human rhinovirus 3C proteases. [PDF]

IUCrJ
Lee J, Lee HL, Kim H, Gil Y, Lee SH, Jung YS, Shin JS, Jo I.   +7 more
europepmc   +1 more source

De N ovo -Designed Miniprotein Inhibits the Enzymatic Activity of the SARS-CoV-2 Main Protease

Tayná Evily de Lima, Emerson G. Moreira, Danilo F. Coêlho, Carlos Cruz, Rafael Dhália, Bruno Leite, Lícya S.S. Xavier, Marta Illana, Gabriel Luz Wallau, Isabelle F. T. Viana, Roberto D. Lins   +10 more
openalex   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Protease profiling in fecal samples: a novel non-invasive diagnostic tool for gastrointestinal disorders. [PDF]

Sci Rep
Baldassar L, Cendron L, Facchin S, Redavid C, Barberio B, Jorkesh A, Dettin M, Pasquato A, Savarino EV.   +8 more
europepmc   +1 more source

Specific Detection of Naturally Occurring Hepatitis C Virus Mutants with Resistance to Telaprevir and Boceprevir (Protease Inhibitors) among Treatment-Naïve Infected Individuals

, 2011
Salvador Fonseca-Coronado, Alejandro Escobar‐Gutiérrez, Karina Ruíz-Tovar, Mayra Cruz‐Rivera, Pilar Rivera-Osorio, Mauricio Vázquez-Pichardo, Juan Carlos Carpio-Pedroza, Juan Alberto Ruiz‐Pacheco, Fernando Cázares, Gilberto Vaughan   +9 more
openalex   +2 more sources

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Protease-mediated maturation of M-PMV reverse transcriptase into a functional heterodimer. [PDF]

Protein Sci
Kapisheva M, Junková P, Vaněk O, Jalovcová Z, Křížová I, Dostálková A, Rumlová M.   +6 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

In vitro synthesis of active recombinant orthoflavivirus nonstructural polyproteins in detergent micelles for biochemical analysis. [PDF]

Npj Viruses
Takahashi H, Uchiage Y, Emura Y, Yamagami R, Abe M, Yoshii K, Tajima S, Lim CK, Hori H, Vasudevan SG, Sawasaki T.   +10 more
europepmc   +1 more source