Results 111 to 120 of about 1,452,849 (304)

Inibidor de protease

, 2014
Os inibidores de protease evitam a maturação das proteínas virais dentro das partículas de HIVEducação Superior::Ciências da Saúde ...
Howard Hughes Medical Institute (HHMI)
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Anthelmintic activity of Leucaena leucocephala protein extracts on Haemonchus contortus

Revista Brasileira de Parasitologia Veterinária
The objective of this study was to evaluate the effects of protein extracts obtained from the plant Leucaena leucocephala on the nematode parasite Haemonchus contortus. The seeds, shell and cotyledon of L.
Alexandra Martins dos Santos Soares, Sandra Alves de Araújo, Suzana Gomes Lopes, Livio Martins Costa Junior   +3 more
doaj   +1 more source

Hepatitis C Drugs: The End of the Pegylated Interferon Era and the Emergence of All-Oral, Interferon-Free Antiviral Regimens: A Concise Review

Canadian Journal of Gastroenterology and Hepatology, 2014
Between 2001 and 2011, the standard of care for chronic hepatitis C virus (HCV) infection was a combination of pegylated interferon (PEGIFN) and ribavirin (RBV).
Alan Hoi Lun Yau, Eric M Yoshida
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

HIV-I Protease Based Inhibitor Discovery [PDF]

, 2013
We can devise a drug (inhibitor) to restrain the activity of gene. As a gene engenders protein/enzyme, so to circumvent the development of any disease causing proteins, we have to stop the activity of that gene.
SWAMY, T ANTHONEY, MOSES, GUMMADI SAMUEL
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Long-term efficacy and safety of a treatment strategy for HIV infection using protease inhibitor monotherapy: 8-year routine clinical care follow-up from a randomised, controlled, open-label pragmatic trial (PIVOT) [PDF]

BACKGROUND: Treatment-simplification strategies are important tools for patient-centred management. We evaluated long-term outcomes from a PI monotherapy switch strategy.
Fox, J, Clarke, Amanda, Paton, NI, Gompels, Mark, Clarke, A, Chen, Fabian, Dunn, DT, Orkin, C, Sanders, K, Lee, V, Lee, Vincent, Winston, Alan, Arenas-Pinto, A, Protease Inhibitor monotherapy Versus Ongoing Triple therapy (PIVOT) Trial Team, Dunn, David T, Arenas-Pinto, Alejandro, Chen, F, Orkin, Chloe, Sanders, Karen, Winston, A, Johnson, M, Williams, Ian, Stöhr, W, Johnson, Margaret, Stöhr, Wolfgang, Williams, I, Paton, Nicholas I, Gompels, M, Fox, Julie, Protease Inhibitor monotherapy Versus Ongoing Triple therapy (PI, Say Quah, Vincent Lee, Nicholas Paton, Alistair Teague, Sris Allan, Moses Kapembwa, Ben Cromerty, Lewis Haddow, Carl De Souza, Lucy Campbell, James Hand, Rebecca Howe, David Stacey, Juan Manuel Tiraboschi, Steve Taylor, Ruth Woodward, Gerry Gilleran, David T. Dunn, Sheena Quaid, Jane Rowlands, Fabiola Martin, Lee Munro, Pierre Pellegrino, Karen Scott, Gary Brook, Kazeem Aderogba, Nicholas I. Paton, David Dockrell, Sue Fleck, Phillip Hay, Emma Beaumont, Brian Angus, Sarah Russell-Sharpe, Rumun Sandhu, Ruth Wilson, Iain Reeves, Scott Mullaney, Mark Hall, Livia Vivas, Elizabeth Green, David Dunn, Sinead McKernan, Sinna Jebakumar, Nellie Nkhoma, Sifiso Mguni, Suzanne Price, Karen Martin, Sarah Douglas, Christine Brewer, Nelson David, David Chadwick, Andrew Freedman, Alejandro Arenas-Pinto, Danielle Mercey, Andrew Phillips, Andrew Crawford-Jones, Yvonne Clowes, Memory Kakowa, Nahum De Esteban, Julie Wollaston, Stephen Kegg, Ellen Owen-Powell, David Lalloo, Jonathan Ainsworth, Brian Gazzard, Ischa Kummeling, Sara Martins, Sara McNamara, Robert James, Andrew Thompson, Estee Torok, Wolfgang Stöhr, John Day, Pat Byrne, Charles Lacey, John Masterson, Ellen White, Fionna van Hooff, Ian Williams, Mark Roberts, Manoj Trivedi, Lynne Smart, Amanda Clarke, Chloe Orkin, Shirley Williams, Cheryl Tanawa, Kamlesh Patel, Andrew DeBurgh-Thomas, Edmund Ong, Jane Minton, Martin Fisher, Wendy Mejewska, Martin Jones, Sally Read, Susie Hennings, Lisa Murthen, Abdel Babiker, Rebecca O'Connell, Pauline Spence, Nicholas Beeching, Zoe Warwick, Caroline Bennett, Veerakathy Harinda, Paton, Nicholas I., Thambiah Balachandran, Tim Peto, Laura Hilton, Linda Mashonganyika, Ed Wilkins, Rebecca Tamaklo, Nigel O'Farrell, Adrian Palfreeman, Sheila Morris, Julie Fox, Louise Jennings, Isabelle Jendrulek, Helen Blackman, Margaret Johnson, Emily Wandolo, Elbushra Herieka, Fabian Chen, Frank Post, Sarah Fidler, Clifford Leen, James Walker, Mark Gompels, Olanike Okolo, Lesley Hagger, Sharmin Obeyesekera, James Calderwood, Alan Winston, Liz Jones, Anele Waters, Dunn, David T., Wendy Hadley, Karen Sanders   +165 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source