Results 101 to 110 of about 645,171 (161)

Alpha-1 Antitrypsin as a Regulatory Protease Inhibitor Modulating Inflammation and Shaping the Tumor Microenvironment in Cancer. [PDF]

Cells
Xiang S, Yang L, He Y, Ding F, Qiao S, Su Z, Chen Z, Lu A, Li F.   +8 more
europepmc   +1 more source

A major Toxoplasma serine protease inhibitor protects the parasite against gut-derived serine proteases and NETosis damage. [PDF]

J Biol Chem
Saffarian M, Romano JD, Grigg ME, Coppens I.   +3 more
europepmc   +1 more source

Discovery of the Clinical Candidate <b>S-892216</b>: A Second-Generation of SARS-CoV-2 3CL Protease Inhibitor for Treating COVID-19. [PDF]

J Med Chem
Unoh Y, Hirai K, Uehara S, Kawashima S, Nobori H, Sato J, Shibayama H, Hori A, Nakahara K, Kurahashi K, Takamatsu M, Yamamoto S, Zhang Q, Tanimura M, Dodo R, Maruyama Y, Sawa H, Watari R, Miyano T, Kato T, Sato T, Tachibana Y.   +21 more
europepmc   +1 more source

Repurposing HIV-Protease Inhibitor Precursors as Anticancer Agents: The Synthetic Molecule RDD-142 Delays Cell Cycle Progression and Induces Autophagy in HepG2 Cells with Enhanced Efficacy via Liposomal Formulation. [PDF]

Int J Mol Sci
Crispo F, Vassallo A, Faraone I, Santarsiere A, Chiummiento L, Martinelli M, Cascelli N, Fernàndez-Busquets X, Miglionico R, Nigro I, Caddeo C, Armentano MF.   +11 more
europepmc   +1 more source

Efficacy of a cysteine protease inhibitor compared with enalapril in murine heart failure models. [PDF]

iScience
Aluja D, Delgado-Tomás S, Barrabés JA, Miró-Casas E, Ruiz-Meana M, Rodríguez-Sinovas A, Benito B, Wang J, Song LS, Ferreira-González I, Inserte J.   +10 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Protease Inhibitors in the Clinic

Medicinal Chemistry, 2005
This review describes the clinical status (based on available information) of experimental drugs that inhibit enzymes called proteases, or more precisely a sub-class of proteases called peptidases that catalyse the hydrolysis of polypeptide main chain amide bonds.
Abbenante, Giovanni, Fairlie , David P.
openaire   +4 more sources

Proteases and protease inhibitors in cancer

Acta Histochemica, 1998
The second conference on 'Proteases and protease inhibitors in cancer' was organized by the American Association for Cancer Research (AACR) and Acta Pathologica Microbiologica et Immunologica Scandinavica (APMIS). To understand the role of proteinases and to develop relevant synthetic inhibitors to stop or slow the progression of cancer, an integrated ...
openaire   +4 more sources

Bacterial protease inhibitors

Medicinal Research Reviews, 2002
AbstractSerine‐, cysteine‐, and metalloproteases are widely spread in many pathogenic bacteria, where they play critical functions related to colonization and evasion of host immune defenses, acquisition of nutrients for growth and proliferation, facilitation of dissemination, or tissue damage during infection. Since all the antibiotics used clinically
SUPURAN, CLAUDIU TRANDAFIR, SCOZZAFAVA, ANDREA, B. W. Clare   +2 more
openaire   +3 more sources

Design of protease inhibitors

Biopolymers, 1981
AbstractThere is a general parallelism in the strategy followed in the design of hormonal peptide analogs and protease inhibitors. However, in the latter, one more dimension has been added with the development of mechanism‐based inhibitors, a dimension that is not yet available for hormonal peptides because of the lack of knowledge about receptor ...
M A, Ondetti, D W, Cushman
openaire   +2 more sources

Protease inhibitor monotherapy

Current Opinion in Infectious Diseases, 2011
The present review focuses on recent data about boosted protease inhibitor monotherapy for maintenance of HIV virological suppression.Until recently most of the trials of boosted protease inhibitor monotherapy have studied lopinavir/ritonavir monotherapy.
Ignacio, Pérez-Valero, Jose R, Arribas
openaire   +2 more sources