Results 81 to 90 of about 1,452,849 (304)

Class of antiretroviral drugs and the risk of myocardial infarction [PDF]

, 2007
BACKGROUND:We have previously demonstrated an association between combination antiretroviral therapy and the risk of myocardial infarction. It is not clear whether this association differs according to the class of antiretroviral drugs.
El-Sadr, W, De Wit, S, Phillips, Andrew, Friis-Moller, Nina, Weber, R, Reiss, Peter, Lundgren, JD, O. Kirk, W. M. El Sadr, Monforte, AD, R. Thiébaut, El-Sadr, Wafaa, R. Weber, Friis-Moller, N, N. Friis Møller, Law, MG, Lundgren, Jens D., Kirk, O, Thiebaut, Rodolphe, Fontas, E, Friis-Møller, Nina, De Wit, Stephane, Sabin, Caroline, P. Reiss, S. De Wit, A. N. Phillips, Sabin, CA, d'Arminio Monforte, Antonella, Law, Matthew G., Reiss, P, E. Fontas, Sabin, Caroline A., Lundgren, Jens D, DAD Study Grp, Monforte, Antonella d'Arminio, Phillips, Andrew N., J. D. Lundgren, Phillips, A, Fontas, Eric, M. G. Law, Weber, Rainer, C. A. Sabin, Kirk, Ole, A. d’Arminio Monforte, Law, Matthew, Lundgren, Jens Dilling, Fontas, E., Weber, R., Thiebault, R, Phillips, A., Monforte, A.D., Sabin, C.A., Wit, S. De, Law, M.G., Sadr, W. El, Reiss, P., D'Arminio Monforte, A   +56 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Inibidor de protease

, 2016
Os inibidores de protease evitam a maturação das proteínas virais dentro das partículas de HIVEducação Superior::Ciências da Saúde ...
Howard Hughes Medical Institute (HHMI)
core   +1 more source

Carbohydrases are Digested by Proteases Present in Enzyme Preparations During in vitro Digestion

The Journal of Poultry Science, 2004
A protease present in an enzyme preparation may digest other enzymes and thus reduces the effectiveness of an enzyme preparation to improve digestibility of animal feeds.
Fuad Saleh, Akira Ohtsuka, Tsuneo Tanaka, Kunioki Hayashi   +3 more
doaj   +1 more source

Purification of protease inhibitor.

, 2014
A. Elution pattern of protease inhibitor on DEAE-Sepharose anion exchange column; B. Elution pattern of protease inhibitor on C18-RP HPLC column; C.
Gaurav Kumar (344052), Arindam Bhattacharyya (533343), Tarun Keswani (533342), K. V. Bhaskara Rao (533345), L. Karthik (533341), S. Sarath Chandar (533344)   +5 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The crosstalk between Dendritic and Natural Killer cells together with the function of Tumor Associated Macrophages (TAM) represent novel cancer-related targets for Human Immunodeficiency Type-1 Protease Inhibitors [PDF]

, 2009
Inflammatory conditions and infections in selected organs increase the risk of cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis and subversion of ...
Ciaglia, Elena
core   +1 more source

Purification and Biochemical Characterization of a New Protease Inhibitor from Conyza dioscoridis with Antimicrobial, Antifungal and Cytotoxic Effects

Molecules, 2020
The main objective of the current study was the extraction, purification, and biochemical characterization of a protein protease inhibitor from Conyzadioscoridis. Antimicrobial potential and cytotoxic effects were also examined.
Aida Karray, Mona Alonazi, Slim Smaoui, Philippe Michaud, Dina Soliman, Abir Ben Bacha   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source