Results 71 to 80 of about 1,452,849 (304)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Thermostable serine protease inhibitor from Death cap (Amanita phalloides)

Journal of Associated Medical Sciences, 2019
Background: Protease inhibitor plays an important role in many biological processes in an organism, its selective binding toward protease potentially tuning down some specific biological processes such as enzymatic catalysis regulation, protein signaling
phichaya khamai, Ketpaillin Chimong, Kritchai Pooncharoen, Widsanusan Chartarrayawadee   +3 more
doaj  

Production of Protease Inhibitor With Penicillium sp. — Optimization of the Medium for Growth in Pellet Form and Cytotoxicity Testing

Engineering in Life Sciences
Penicillium sp. (IBWF 040‐09) produces a protease inhibitor that can potentially be used against the main protease of human African trypanosomiasis. Since the target substance is formed intracellularly (under nutrient limitation), the fungal pellet is ...
Winda Soerjawinata, Shila Prajapati, Isabelle Barth, Xiaohua Lu, Roland Ulber, Thomas Efferth, Percy Kampeis   +6 more
doaj   +1 more source

Gag Determinants of Fitness and Drug Susceptibility in Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1

, 1999
Mutations can accumulate in the protease and gag genes of human immunodeficiency virus in patients who fail therapy with protease inhibitor drugs. Mutations within protease, the drug target, have been extensively studied.
Pillay, D., Boinett, C.J., Towers, G.J., Parry, C.M., Kohli, A., McCormick, A.L., A. Kohli, C. J. Boinett, G. J. Towers, C. M. Parry, A. L. McCormick, D. Pillay   +11 more
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Protease and inhibitor concentrations.

, 2015
a Parentheses contain estimated protease concentrationb Not done, due to insufficient inhibitionProtease and inhibitor concentrations.
Shilpa Nimishakavi (734393), George H. Caughey (339258), Wilfred W. Raymond (734392), Dieter C. Gruenert (815805)   +3 more
core   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Protease-anti-protease compartmentalization in SARSCoV-2 ARDS: therapeutic implications

, 2022
Background: Interleukin-6 (IL-6) is elevated in SARS-CoV-2 infection. IL-6 regulates acute-phase proteins, such as alpha-1 antitrypsin (AAT), a key lung anti-protease.
Noel G McElvaney (7895978), Ross E Zumwalt (12189020), Cormac McCarthy (1849417), Jennifer Clarke (7899281), Emer Reeves (7895438), Patrick W. Mallon (6269702), Robert S Hagan (12189005), Oisin Mcelvaney (7898561), Jose L Torres-Castillo (12189004), Suzanne L Meinig (12189002), Natalie McEvoy (7899251), Gerard Curley (7897901), Leigh B Thorne (12189014), Oliver McElvaney (7898186), Takanori Asakura (3551786), Richard C Boucher (12189023), Tomas Carroll (7896269), Kenichi Okuda (12189021), Mark Murphy (7895882), Grace Hogan (7895543), Alain Borczuk (451970), Matthew C Wolfgang (12189022), Yu Mikami (673193), Claudie Gabillard (7899800)   +23 more
core   +1 more source

Mice lacking protease nexin-1 show delayed structural and functional recovery after sciatic nerve crush [PDF]

, 2007
Multiple molecular mechanisms influence nerve regeneration. Because serine proteases were shown to affect peripheral nerve regeneration, we performed nerve crush experiments to study synapse reinnervation in adult mice lacking the serpin protease nexin-1
Atanasoski, Suzana, Suter, Ueli, Kvajo, Mirna, Fayard, Bérengère, Moreno, Eliza, Lino, Maria Maddalena, Brenner, Hans Rudolf, Monard, Denis, Atanasoski S, Fayard B, Moreno E, Monard D, Lino MM, Suter U, Brenner HR, Kvajo M   +15 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source