Results 151 to 160 of about 1,452,849 (304)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Identification of a Potent Pan-Coronaviral Main Protease Inhibitor. [PDF]

J Med Chem
Chen P, Strunk U, Arutyunova E, Lu J, Chen SA, Demmon S, Maplethorpe C, Kandadai AS, Shields J, Saffran HA, Lamer T, Fischer C, Van Oers TJ, Turner Z, Leong P, Iyyathurai J, Young HS, Bai B, Vederas JC, Nieman JA, Joyce MA, Tyrrell DL, Lemieux MJ.   +22 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

The Plant Protease Inhibitor EcTI Suppresses Melanoma Progression In Vivo. [PDF]

Molecules
Bonturi CR, Salu BR, Lie KCM, Bonini M, Sinigaglia RC, Alvarez-Flores MP, Chudzinski-Tavassi AM, Selistre-de-Araujo HS, Oliva MLV.   +8 more
europepmc   +1 more source

Gastric Proteases and Protease Inhibitors

Gastroenterology, 1967
M D, Turner, L L, Miller, H L, Segal
openaire   +2 more sources

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Late-stage Diversification of HIV-1 Protease Inhibitor via SuFEx Click Chemistry. [PDF]

Synthesis (Stuttg)
Khanal B, Yamanushkin P, Gold B.
europepmc   +1 more source

Asunaprevir, a protease inhibitor for the treatment of hepatitis C infection

, 2014
Ivan Gentile,1 Antonio Riccardo Buonomo,1 Emanuela Zappulo,1 Giuseppina Minei,1 Filomena Morisco,2 Francesco Borrelli,1 Nicola Coppola,3 Guglielmo Borgia1 1Section of Infectious Diseases, 2Section of Gastroenterology, Department of Clinical Medicine and ...
Buonomo AR, Morisco F, Borrelli F, Coppola N, Minei G, Borgia G, Zappulo E, Gentile I   +7 more
core  

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Macrophage restriction in <i>Drosophila</i> wounds and tumors via a matrix degradation-moderating protease inhibitor. [PDF]

Sci Adv
Sakai Y, Adiga K, Nawabi M, Mendez-Lopez S, Hsi TC, Bilder D.   +5 more
europepmc   +1 more source