Results 161 to 170 of about 902,862 (301)

Discovery of EGT710, an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease Inhibitor. [PDF]

J Med Chem
Papillon JPN, Yuan J, Hesse MJ, Zhang L, Robinson RI, Ware NF, Hornak V, Karki RG, Kirrane T, Garland K, Joseph S, Moquin SA, Lakshminarayana SB, Tandeske L, Dovala D, Knapp M, Ornelas E, Fuller D, Ho PI, Xie X, Vulic K, Skolnik SM, Gao J, Zambrowski M, Spiess M, Duca JS, Busby SA, Schirle M, Robinson M, Shi PY, Moser HE, Sarko C, Bradner JE, Diagana TT, Tallarico JA.   +34 more
europepmc   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Regioselective multicomponent synthesis of α-boryl ureas: discovery of a potent main protease inhibitor. [PDF]

Org Biomol Chem
Gyasi YI, Nyalata S, Pa S, Gunasekera D, Vulupala VR, Mallampudi NR, Ramidi GR, Xu S.   +7 more
europepmc   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Sequential Optimization Approach Toward an Azapeptide-Based SARS-CoV-2 Main Protease Inhibitor. [PDF]

Arch Pharm (Weinheim)
Voget R, Steiger V, Breidenbach J, Sylvester K, Müller-Ruttloff C, Yang CC, Ziebuhr J, Sträter N, Müller CE, Gütschow M.   +9 more
europepmc   +1 more source

Multiplex Modular Nanorobotic Systems with Catalytic Activity under Magnetic Navigation

Advanced Functional Materials, EarlyView.
We present modular nanorobots composed of a magnetic propulsion module and different extension modules carrying functional activities, assembled via DNA base pairing. The system integrates propulsion, optical tracking, enzymatic catalysis, and cell docking in a programmable manner.
Voichita Mihali, Xinan Huang, Lucie Motyckova, Nicolas Moreno Gomez, Michal Skowicki, Cora‐Ann Schoenenberger, Peer Fischer, Cornelia G. Palivan   +7 more
wiley   +1 more source

YL1004 is a SARS-CoV-2 papain-like protease inhibitor with immunomodulatory and antiviral activity in mice. [PDF]

Nat Commun
Nan J, Shuai H, Qiao J, Zeng R, Du L, Chen Y, Yoon C, Hu J, Guo W, Wang L, Huang C, Zhu L, Li Y, Zhang S, Deng X, Sun J, Du L, Ma R, Huang Q, Lei J, Chu H, Yang S.   +21 more
europepmc   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Downregulation of the Transglutaminase 2-NF-κB Inflammatory Axis by a Fusion Protein of Cementoin and Secretory Leukocyte Protease Inhibitor Reduces Corneal Angiogenesis. [PDF]

Int J Mol Sci
Salica JP, Potilinski MC, Ortiz G, Maffia PC, Guerrieri D, Chuluyan E, Gallo JE.   +6 more
europepmc   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source