Results 161 to 170 of about 1,452,849 (304)

High throughput in vivo protease inhibitor selection platform

, 2017
The invention relates to a recombinant microbial cell comprising a selection platform for screening for a protease inhibitor, wherein the platform comprises transgenes encoding a protease having selective peptide bond cleavage activity at a recognition ...
Van Der Helm, Eric, Sommer,, Morten
core  

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Preclinical evaluation of cysteine protease-inhibitor aloxistatin (E64d) for heart failure therapy. [PDF]

J Mol Med (Berl)
Jordan M, Stucki-Koch A, Schinke M, Willmer L, Senne I, Abbas N, Bentele M, Oldenkott D, Lachmann N, Feldbrügge L, Puffert R, Fangmann J, Ramm R, Thum T, Sewald K, Schmidt K, Fiedler J.   +16 more
europepmc   +1 more source

Method for the detection and possible quantification of activity of at least one protease inhibitor in a sample to be analyzed, as well as a method for the determination of the (residual) activity of one (or more) discrete (iso)type(s) protease inhibitor(s) and application of the method for the determination of the total (residual) activity of a sample, if necessary after processing such as a process for the elimination or inactivation of protease inhibitor(s)

, 1995
The present invention relates to a method for detecting and, if necessary, quantifying the activity of at least one protease inhibitor in a mixture to be analysed, where a) the mixture to be analysed or a sample thereof is brought into contact with at ...
Meijer, M.M.T., Amerongen, A., van
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Asymmetric Synthesis of the HIV Protease Inhibitor TMC-126, a PMX Antimalarial Protease Inhibitor, and a Putative COVID-19 Inhibitor Using a Highly Stereoselective Glycolate Aldol Addition Reaction Pathway. [PDF]

ACS Omega
Affram KA, Carter A, Breede A, Kimsey A, Hemeson G, Semakieh B, Martinez M, Ayim E, Odeh J, Hitchcock SR.   +9 more
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Conkazal-M1 from the MKAVA family of conotoxins: A dual-function protease inhibitor and neuroactive peptide. [PDF]

Protein Sci
Hackney CM, Koch TL, Ryding NL, Rogalski A, Chase K, Giglio ML, Espino SS, Acyatan ZG, Watkins M, Olivera BM, Safavi-Hemami H, Teilum K, Ellgaard L.   +12 more
europepmc   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

Sero-epidemiological and functional evaluation of IgG specific for a cysteine protease inhibitor of <i>Plasmodium falciparum</i>, falstatin. [PDF]

Infect Immun
Bhardwaj J, Gaskin EL, Holla P, De Los Santos O, Doumbo S, Kayentao K, Ongoiba A, Traore B, Crompton PD, Tran TM.   +9 more
europepmc   +1 more source