Results 211 to 220 of about 3,932,956 (396)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Secretory leukocyte protease inhibitor (SLPI) promotes cholangiocarcinoma progression via inflammation-associated and vasculogenic mechanisms. [PDF]

PLoS One
Chueajedton K, Chueaiphuk C, Inpad J, Kumphune S, Kaewkong W, Surangkul D, Sawanyawisuth K, Cha'on U, Phimsen S.   +8 more
europepmc   +1 more source

De N ovo -Designed Miniprotein Inhibits the Enzymatic Activity of the SARS-CoV-2 Main Protease

Tayná Evily de Lima, Emerson G. Moreira, Danilo F. Coêlho, Carlos Cruz, Rafael Dhália, Bruno Leite, Lícya S.S. Xavier, Marta Illana, Gabriel Luz Wallau, Isabelle F. T. Viana, Roberto D. Lins   +10 more
openalex   +1 more source

Expedited SARS‐CoV‐2 Main Protease Inhibitor Discovery through Modular ‘Direct‐to‐Biology’ Screening [PDF]

Harry Wilders, George S. Biggs, Sam M. Rowe, Emma E. Cawood, Alan R. Rendina, Emma K. Grant, Ioannis G. Riziotis, Jonathan Pettinger, David J. Fallon, Mark Skehel, David House, Nicholas C. O. Tomkinson, Jacob T. Bush   +12 more
openalex   +1 more source

Oridonin Inhibits SARS‐CoV‐2 by Targeting Its 3C‐Like Protease

, 2022
Baisen Zhong, Weiyu Peng, Shan Du, Bingyi Chen, Yajuan Feng, Xinfeng Hu, Qi Lai, Shujie Liu, Zhong‐Wei Zhou, Pengfei Fang, Wu Yan, Feng Gao, Huihao Zhou, Litao Sun   +13 more
openalex   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

An Insight into the Interaction Between α-Ketoamide-Based Inhibitor and Coronavirus Main Protease: A Detailed in Silico Study

, 2020
Snehasis Banerjee
openalex   +1 more source

Effects of Storage Time and Exogenous Protease Inhibitors on Plasma Protein Levels [PDF]

, 2006
Saleh Ayache, Monica C. Panelli, Francesco M. Marincola, David F. Stroncek   +3 more
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Secretory Leukocyte Protease Inhibitor: A Pleiotropic Molecule for the Potential Diagnosis of and Therapy for Acute Kidney Injury. [PDF]

Int J Mol Sci
Chen R, Gu S, Xiong F, Ji L, Zhang ZJ, Yang B, Wu Y.   +6 more
europepmc   +1 more source