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The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Immunoregulation mediated by the enzyme inhibitory activity of helminth-derived serine protease inhibitor affects the protective efficiency of vaccines. [PDF]

Virulence
Shi W, Liu Y, Bai X, Liang Y, Zhang S, Sun L, Lin W, Liu X, Xu N.   +8 more
europepmc   +1 more source

Serine protease inhibitor dipetalogastin-like from Galleria mellonella is involved in insect immunity. [PDF]

Sci Rep
Kordaczuk J, Sułek M, Mak P, Pawlikowska-Pawlęga B, Wojda I.   +4 more
europepmc   +1 more source

Anti-Melanoma Activity and Potential Mechanism of Purified Potato Protease Inhibitor. [PDF]

Foods
Li Q, Jiang L, Chen N, Wang X, Yao J, Su Z, Zhao S.   +6 more
europepmc   +1 more source

Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral Activity. [PDF]

J Med Chem
Hossain MA, Mayo AK, Ghoshal A, Taft-Benz S, Anderson E, Morales NL, Pressey KD, Vargason A, Brouwer KLR, Moorman NJ, Heise MT, Willson TM.   +11 more
europepmc   +1 more source

Ligand Versatility and Resistance Mechanism of Monotherapy-Grade HIV-1 Protease Inhibitor GRL-142 Binding the Multidrug Resistant Variant p51: Insights from 1 μs MD Simulations. [PDF]

J Chem Inf Model
Arias A, Cappelli C, Restrepo A, Alí-Torres J, Gómez S.   +4 more
europepmc   +1 more source

Secretory leucocyte protease inhibitor regulates bone metabolism and inflammation in experimental mouse periodontitis. [PDF]

Commun Biol
Sasagawa K, Domon H, Hirayama S, Maekawa T, Isono T, Tabeta K, Terao Y.   +6 more
europepmc   +1 more source

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Cysteine Proteases and Their Inhibitors

Chemical Reviews, 1997
Tanja Schirmeister, Hans-Hartwig Otto
exaly   +4 more sources