Results 301 to 310 of about 3,932,956 (396)

Design, synthesis and activity evaluation of dual-target inhibitors against papain-like and main proteases of porcine epidemic diarrhea virus

Jiashu Chen, Yuxi Lin, Chenxia Gao, Zhuoya Wang, Yue Xu, Yuanyuan Zhao, Chao Xie, Chao Liu, Nan Zhou, Wenlong Shan, Weijian Zhuang, Hongyun Qin, Cong Shi, Ruihua Liu, Zemin Wang, Xing Pan, Jiawen Zhu, Bo Wang, Xiangqian Li, Dayong Shi   +19 more
openalex   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

Comparative Transcriptome Analysis Reveals Expression of Defense Pathways and Specific Protease Inhibitor Genes in Solanum lycopersicum in Response to Feeding by Tuta absoluta. [PDF]

Insects
Zhou Y, Pan Y, Liu J, Yang W, Shen G.
europepmc   +1 more source

The P1 reactive site methionine residue of ecotin is not crucial for its specificity on target proteases. A potent inhibitor of pancreatic serine proteases from Escherichia coli.

, 1994
Ihn Sik Seong, Hyun‐Jae Lee, Jaeho Seol, Sojung Park, C.S. Lee, Se Won Suh, Y.M. Hong, M. S. Kang, Doo Bong Ha, Chin Ha Chung   +9 more
openalex   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

Microsporidian Nosema bombycis secretes serine protease inhibitor to suppress host cell apoptosis via Caspase BmICE. [PDF]

PLoS Pathog
Ran M, Bao J, Li B, Shi Y, Yang W, Meng X, Chen J, Wei J, Long M, Li T, Li C, Pan G, Zhou Z.   +12 more
europepmc   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

DEFINE: A Prospective, Randomized, Phase 4 Trial to Assess a Protease Inhibitor-Based Regimen Switch Strategy to Manage Integrase Inhibitor-Related Weight Gain. [PDF]

Clin Infect Dis
Anderson D, Ramgopal M, Hagins DP, Lee J, Simonson RB, Hsu TH, Xu P, Ahmad N, Short WR.   +8 more
europepmc   +1 more source

The mean activities of acidic, neutral, and alkaline protease inhibitors in the hemolymph and the tergite 3, tergite 5 and sternite fat bodies in the 7-day-old workers fed sugar candy only and in those receiving sugar candy with various pollen additions; a, b – discrepancies between the workers administered pollen and the control ones in identical tissues/sites are meaningful at p 

Maciej Sylwester Bryś (21567547), Krzysztof Olszewski (644514), Aneta Strachecka (3966995)   +2 more
openalex   +1 more source

Spatial Patterning of Modular Gelatin‐Peroxide Microspheres in Melt‐Electrowritten Scaffolds Provides Controlled Oxygen Generation and Mitigates Hypoxia and Cytotoxicity

Advanced Healthcare Materials, EarlyView.
A bioassembly approach is described using photo‐crosslinked gelatin‐based microgels containing calcium peroxide (CaO2) to generate oxygen (O2) and enhance cell survival in hypoxic conditions (1% O2). Bioassembly enables spatial patterning of individual CaO2‐laden and mesenchymal stem cell (MSC)‐laden microgels and allows for decoupling and mitigating ...
Axel E. Norberg, F. Max Yavitt, Ezgi Bakirci, Khoon Lim, Tim B. F. Woodfield, Gabriella C. J. Lindberg   +5 more
wiley   +1 more source