Results 321 to 330 of about 3,932,956 (396)

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source

Correlation of Experimental and Calculated Inhibition Constants of Protease Inhibitor Complexes. [PDF]

Int J Mol Sci
Goettig P, Chen X, Harris JM.
europepmc   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Low Secretory Leukocyte Protease Inhibitor (SLPI)-Level Potentiates Alternaria Extract-Induced T-Helper 2 (Th2) Airway Inflammation via the Interleukin-33 (IL-33) Pathway. [PDF]

Cureus
Hirano T, Koarai A, Ohkouchi S, Sugiura H, Kurosawa H.   +4 more
europepmc   +1 more source

Amine‐Functionalized Chitosan/dECM Composite Promotes Cutaneous Regeneration and Hair Follicle Activation by Regulating Oxidative Stress and Inflammation

Advanced Healthcare Materials, EarlyView.
An amine‐functionalized chitosan and hydrolyzed dECM composite promotes cutaneous regeneration by modulating oxidative stress and inflammatory pathways. The material accelerates wound closure and stimulates hair follicle activation in UV‐damaged cutaneous tissue.
Yu‐Jin Kim, Seokheon Hong, Jae Hwi Lee, Jongmin Lee, Jae Jun Kang, Jiseon Bae, Jino Kim, Dong‐Hwee Kim, Jin Yoo, Mi Sun Cha, Su Hee Kim, Youngmee Jung   +11 more
wiley   +1 more source

Therapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis. [PDF]

Nat Commun
Wang Y, Han J, Yang G, Zheng S, Zhou G, Liu X, Cao X, Li G, Zhang B, Xie Z, Li L, Zhang M, Li X, Chen M, Zhang S.   +14 more
europepmc   +1 more source

HIV drug resistance, early treatment outcomes and impact of guidelines compliance after protease inhibitor-based second-line failure in a dedicated resistance clinic in western Kenya: a retrospective cohort study. [PDF]

J Int AIDS Soc
Humphrey JM, Ali SM, DeLong A, Novitsky V, Sang E, Jawed B, Kemboi E, Ngetich C, Goodrich S, Gardner A, Hogan JW, Kantor R.   +11 more
europepmc   +1 more source

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19. [PDF]

Nat Commun
Lu Y, Yang Q, Ran T, Zhang G, Li W, Zhou P, Tang J, Dai M, Zhong J, Chen H, He P, Zhou A, Xue B, Chen J, Zhang J, Yang S, Wu K, Wu X, Tang M, Zhang WK, Guo D, Chen X, Chen H, Shang J.   +23 more
europepmc   +1 more source

Identification of the interaction between MAPK1 and <i>Eimeria acervulina</i> serine protease inhibitor: a preliminary functional study. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Lian L, Sun H, Wang J, Li W, Sheng Y, Gong X, Sun Q, Wang P, Zheng Y, Song H.   +9 more
europepmc   +1 more source

Serine protease inhibitor, SerpinA3n, regulates cardiac remodelling after myocardial infarction. [PDF]

Cardiovasc Res
Sun Q, Chen W, Wu R, Tao B, Wang P, Sun B, Alvarez JF, Ma F, Galindo DC, Maroney SP, Saviola AJ, Hansen KC, Li S, Deb A.   +13 more
europepmc   +1 more source