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Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling. [PDF]

Viruses
Alvarez N, Adam GC, Howe JA, Sharma V, Zimmerman MD, Dolgov E, Rasheed R, Nizar F, Sahay K, Nelson AM, Park S, Zhou X, Burlein C, Fay JF, Iwamoto DV, Bahnck-Teets CM, Getty KL, Lin Goh S, Salhab I, Smith K, Boyce CW, Cabalu TD, Murgolo N, Fox NG, Mayhood TW, Shurtleff VW, Layton ME, Parish CA, McCauley JA, Olsen DB, Perlin DS.   +30 more
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Protease inhibitor monotherapy

Current Opinion in Infectious Diseases, 2011
The present review focuses on recent data about boosted protease inhibitor monotherapy for maintenance of HIV virological suppression.Until recently most of the trials of boosted protease inhibitor monotherapy have studied lopinavir/ritonavir monotherapy.
Ignacio, Pérez-Valero, Jose R, Arribas
openaire   +3 more sources

Bacterial protease inhibitors

Medicinal Research Reviews, 2002
AbstractSerine‐, cysteine‐, and metalloproteases are widely spread in many pathogenic bacteria, where they play critical functions related to colonization and evasion of host immune defenses, acquisition of nutrients for growth and proliferation, facilitation of dissemination, or tissue damage during infection. Since all the antibiotics used clinically
SUPURAN, CLAUDIU TRANDAFIR, SCOZZAFAVA, ANDREA, B. W. Clare   +2 more
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Proteases, protease inhibitors and radiation carcinogenesis

International Journal of Radiation Biology, 2021
The purpose of the studies described in this mini review article was to identify nontoxic compounds that could prevent or suppress the radiation induced malignant transformation of cells and be useful as human cancer preventive agents.(1) Many different types of potential anticarcinogenic substances were evaluated initially for their abilities to ...
openaire   +2 more sources

HIV-Protease Inhibitors

New England Journal of Medicine, 1998
Inhibitors of human immunodeficiency virus (HIV)–encoded protease, combined with nucleoside analogues with antiretroviral activity, cause profound and sustained suppression of viral replication, reduce morbidity, and prolong life in patients with HIV infection.1–3 Recent guidelines recommend that initial treatment of all HIV-infected patients include ...
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Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection

Annals of Internal Medicine, 2000
D. Paterson, S. Swindells, Jeffrey A. Mohr, M. Brester, E. Vergis, C. Squier, M. Wagener, Nina Singh   +7 more
semanticscholar   +1 more source

HIV protease inhibitors

AIDS, 1996
A, Carr, D A, Cooper
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Protease inhibitor therapy for hepatitis C virus-infection

Expert Opinion on Pharmacotherapy, 2018
P. Leuw, Christoph Stephan
semanticscholar   +1 more source