Results 151 to 160 of about 368,214 (310)

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing

Clinical pharmacology and therapy, 2016
Roseann S. Gammal, Michael H. Court, Cyrine E. Haidar, O. Iwuchukwu, Aditya H. Gaur, Maria L. Alvarellos, Chantal Guillemette, Jeffrey L. Lennox, Michelle Whirl‐Carrillo, Sean Brummel, M. Ratain, Teri E. Klein, Bruce R Schackman, K. Caudle, David W. Haas   +14 more
semanticscholar   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

Decoding of Inconsistent Biological Data: A Critical Step toward Enhanced AI Predictivity in Drug Discovery. [PDF]

ACS Pharmacol Transl Sci
Behnam MAM, Cavalli A, Lousa D, Soares CM, Klein CD.   +4 more
europepmc   +1 more source

Breakdown of C3 complement and IgG in peritonitis exudate-pathophysiological aspects and therapeutic approach [PDF]

, 1988
Billing, A., Fröhlich, D., Jochum, Marianne, Kortmann, H., Redl, H., Schlag, G.   +5 more
core  

Relationship between angiotensinogen, alpha-1-protease inhibitor elastase complex, antithrombin III and C-reactive protein in septic ARDS [PDF]

, 1990
Hilgenfeldt, U., Jochum, Marianne, Kellermann, W., Kienapfel, G.   +3 more
core   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Multifaceted anticancer activity of nafamostat mesylate in human fibrosarcoma: first evidence of mitochondrial apoptosis and suppressed MMP-2/-9 mRNA expression. [PDF]

BMC Pharmacol Toxicol
Yildirim C, Bakar-Ates F.
europepmc   +1 more source

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

Advanced Science, EarlyView.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu, Tianyang Wu, Jiayi Wang, Xinxing Du, Xinrui Wu, Yanhao Dong, Zehong Peng, Penghui Liao, Zirui Guo, Zheyu Liu, Kenneth J Pienta, Yinjie Zhu, Jiahua Pan, Liang Dong, Wei Xue   +14 more
wiley   +1 more source

PI3K/AKT/eNOS Modulation and Angiotensin II Suppression by <i>Dryopteris crassirhizoma</i> Rhizome Extract: Computational and Experimental Evidence. [PDF]

ACS Omega
Kim J, Park J, Shin S, Kim Y, Jung J, Bu Y, Choi HY, Lee K.   +7 more
europepmc   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source