Results 151 to 160 of about 134,020 (288)

1200 FINDINGS FROM CLINICAL VIROLOGY STUDIES ON SOVAPREVIR, A PHASE 2 HCV NS3 PROTEASE INHIBITOR, INDICATE A HIGH PHARMACOLOGICAL BARRIER TO VIRAL RESISTANCE

, 2013
J. Fabrycki, Yongsen Zhao, D. Patel, Bing Yang, Steven D. Podos, Weiying Yang, H. Robison, L. Robarge, Hetal S. Kocinsky, Elizabeth Olek, Milind Deshpande, Meei‐Li Huang   +11 more
openalex   +1 more source

Relationship between angiotensinogen, alpha-1-protease inhibitor elastase complex, antithrombin III and C-reactive protein in septic ARDS [PDF]

, 1990
Hilgenfeldt, U., Jochum, Marianne, Kellermann, W., Kienapfel, G.   +3 more
core   +1 more source

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Direct Oral Anticoagulant-Related Bleeding in Atrial Fibrillation Patients Leads to <i>ADAMTS7</i> Promoter Demethylation. [PDF]

Genes (Basel)
Ragia G, Thomopoulos T, Pallikarou M, Atzemian N, Maslarinou A, Chalikias G, Trikas A, Tziakas DN, Manolopoulos VG.   +8 more
europepmc   +1 more source

Breakdown of C3 complement and IgG in peritonitis exudate-pathophysiological aspects and therapeutic approach [PDF]

, 1988
Billing, A., Fröhlich, D., Jochum, Marianne, Kortmann, H., Redl, H., Schlag, G.   +5 more
core  

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source

Machine Learning-Guided Screening and Molecular Docking for Proposing Naturally Derived Drug Candidates Against MERS-CoV 3CL Protease. [PDF]

Int J Mol Sci
Ouassaf M, Mazri R, Khan SU, Rengasamy KRR, Alhatlani BY.   +4 more
europepmc   +1 more source

Calcineurin controls the expression of numerous genes in cerebellar granule cells [PDF]

, 2003
Ashby, Dominique S, Freeman, Tom C, Fresu, Luigia, Genazzani, Armando A, Kramer, Dana   +4 more
core   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source

i-DENV: development of QSAR based regression models for predicting inhibitors targeting non-structural (NS) proteins of dengue virus. [PDF]

Front Pharmacol
Gautam S, Thakur A, Kumar M.
europepmc   +1 more source